https://transhumanist.ru/index.php?action=history&feed=atom&title=ADRA2A 2026-06-09T04:03:09Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ADRA2A&diff=5829&oldid=prev 2021-05-12T14:54:50Z

<p>Новая страница: «Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) [ADRA2R] [ADRAR] ==Publicat...»</p> <p><b>Новая страница</b></p><div>Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) [ADRA2R] [ADRAR]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=α2A-Adrenergic Receptor Inhibits the Progression of Cervical Cancer Through Blocking PI3K/AKT/mTOR Pathway.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33116632<br /> |abstract=The study aimed to investigate the effect of α2A-adrenergic receptor ([[ADRA2A]]) on cervical cancer and the potential mechanisms of [[ADRA2A]] on phosphatidylinositol 3&#039;-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway in cervical cancer cells. In our study, [[ADRA2A]] expression was evaluated by analyzing cervical cancer RNA sequencing dataset from the GEPIA. The prognostic values of [[ADRA2A]] were evaluated by Kaplan-Meier method using the Cancer Genome Atlas (TCGA) database data. In addition, the expression of [[ADRA2A]] in cervical cancer cell lines was detected by qRT-PCR and Western blot. Subsequently, the roles of [[ADRA2A]] on cell proliferation, apoptosis, migration, invasion and senescence in HeLa and SiHa cells were evaluated. Moreover, tumorigenesis in nude mice was used to investigate the role of [[ADRA2A]] in vivo. We also detected the expression changes of key factors in PI3K/Akt/mTOR pathway after overexpression and silencing of [[ADRA2A]] in HeLa and SiHa cells. [[ADRA2A]] expression was significantly downregulated in cervical cancer tissues and cell lines. The high expression of [[ADRA2A]] was significantly associated with a better prognosis in cervical cancer patients. [[ADRA2A]] overexpression significantly suppressed cell proliferation, migration and invasion, and promoted cell senescence and apoptosis in cervical cancer cells. On the contrary, silencing [[ADRA2A]] dramatically facilitated cell proliferation, migration and invasion, and inhibited cell senescence and apoptosis in cervical cancer cells. The expressions of p-PI3K, p-AKT and p-mTOR in cervical cancer cells were notably decreased by [[ADRA2A]] overexpression and increased by silencing [[ADRA2A]]. In addition, we also confirmed that [[ADRA2A]] overexpression could suppress the xenograft tumor growth in vivo. Our study demonstrated that [[ADRA2A]] could suppress cell proliferation, migration and invasion, as well as promote cell senescence and apoptosis through inhibiting PI3K/Akt/mTOR pathway in cervical cancer.<br /> <br /> |keywords=* ADRA2A<br /> * PI3K/Akt/mTOR pathway<br /> * cervical cancer<br /> * metastasis<br /> * proliferation<br /> * senescence<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574911<br /> }}</div>

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