https://transhumanist.ru/index.php?action=history&feed=atom&title=ADNP2 2026-06-15T12:32:13Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ADNP2&diff=5827&oldid=prev 2021-05-12T14:54:43Z

<p>Новая страница: «Activity-dependent neuroprotector homeobox protein 2 (ADNP homeobox protein 2) (Zinc finger protein 508) [KIAA0863] [ZNF508] ==Publications== {{medline-entry |t...»</p> <p><b>Новая страница</b></p><div>Activity-dependent neuroprotector homeobox protein 2 (ADNP homeobox protein 2) (Zinc finger protein 508) [KIAA0863] [ZNF508]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[[ADNP]] differentially interact with genes/proteins in correlation with aging: a novel marker for muscle aging.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31264075<br /> |abstract=Activity-dependent neuroprotective protein ([[ADNP]]) is essential for embryonic development with [[ADNP]] mutations leading to syndromic autism, coupled with intellectual disabilities and motor developmental delays. Here, mining human muscle gene-expression databases, we have investigated the association of [[ADNP]] transcripts with muscle aging. We discovered increased [[ADNP]] and its paralogue [[[[ADNP]]2]] expression in the vastus lateralis muscle of aged compared to young subjects, as well as altered expression of the [[ADNP]] and the [[[[ADNP]]2]] genes in bicep brachii muscle of elderly people, in a sex-dependent manner. Prolonged exercise resulted in decreased [[ADNP]] expression, and increased [[[[ADNP]]2]] expression in an age-dependent manner in the vastus lateralis muscle. [[ADNP]] expression level was further correlated with 49 genes showing age-dependent changes in muscle transcript expression. A high degree of correlation with [[ADNP]] was discovered for 24 genes with the leading gene/protein being [[NMNAT1]] (nicotinamide nucleotide adenylyl transferase 1). Looking at correlations differentiating the young and the old muscles and comparing protein interactions revealed an association of [[ADNP]] with the cell division cycle 5-like protein (CDC5L), and an aging-muscle-related interactive pathway in the vastus lateralis. In the bicep brachii, very high correlation was detected with genes associated with immune functions as well as mitochondrial structure and function among others. Taken together, the results suggest a direct association of [[ADNP]] with muscle strength and implicate [[ADNP]] fortification in the protection against age-associated muscle wasting.<br /> |mesh-terms=* Adult<br /> * Aged, 80 and over<br /> * Aging<br /> * Female<br /> * Homeodomain Proteins<br /> * Humans<br /> * Male<br /> * Muscle, Skeletal<br /> * Nerve Tissue Proteins<br /> * Nicotinamide-Nucleotide Adenylyltransferase<br /> * Physical Endurance<br /> * Sarcopenia<br /> * Transcription, Genetic<br /> |keywords=* Aging<br /> * Endurance exercise<br /> * Sarcopenia<br /> * Sex<br /> * Transcription profile<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702513<br /> }}</div>

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