https://transhumanist.ru/index.php?action=history&feed=atom&title=ADD1 2026-05-16T21:02:24Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ADD1&diff=5445&oldid=prev 2021-05-12T13:44:18Z

<p>Новая страница: «Alpha-adducin (Erythrocyte adducin subunit alpha) [ADDA] ==Publications== {{medline-entry |title=Effects of genetic variation in adducin on left ventricular dia...»</p> <p><b>Новая страница</b></p><div>Alpha-adducin (Erythrocyte adducin subunit alpha) [ADDA]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18475162<br /> |abstract=We investigated the possible association between left ventricular diastolic function and the [[ADD1]] Gly460Trp and [[ADD3]] IVS11 386A&gt;G polymorphisms alone and in combination. In a family-based population study (473 subjects; 50.5% women; mean age 50.5 years), we measured early (Ea) and late (Aa) diastolic peak velocities of the mitral annulus by tissue Doppler imaging. In multivariate-adjusted analyses, we investigated phenotype-genotype associations, while accounting for confounders and family structure. Lateral Ea/Aa ratio was higher in [[ADD1]] Trp allele carriers than in GlyGly homozygotes (1.51 vs. 1.40; P = 0.005) and was lower in [[ADD3]] A allele carriers than in GG homozygotes (1.42 vs. 1.55; P = 0.005). The effects of [[ADD1]] on the lateral Ea and Ea/Aa weakened with older age (P &lt; 0.05). The best fitting model for lateral Ea and Ea/Aa included [[ADD1]], [[ADD3]], and the three-way interaction term of both genes with age. Below the age of 50 years, the lateral Ea/Aa ratio was higher in [[ADD1]] Trp allele carriers than in GlyGly homozygotes (1.91 vs. 1.73; P = 0.006), particularly in the presence of [[ADD3]] GG homozygosity (2.46 vs. 1.80; P = 0.0008). In older subjects, these phenotype-genotype associations were not significant (P &gt; 0.20). Transmission of the [[ADD1]] Trp allele to offspring was associated with higher lateral Ea ( 0.91; P = 0.026) and Ea/Aa ratio ( 0.23; P = 0.0008). Our population-based study demonstrated that left ventricular diastolic relaxation is modulated by genetic variation in [[ADD1]] and [[ADD3]]. This association was more prominent in younger subjects in whom longstanding environmental factors and ageing are less likely to mask genetic effects.<br /> |mesh-terms=* Adult<br /> * Aged<br /> * Aging<br /> * Belgium<br /> * Blood Flow Velocity<br /> * Calmodulin-Binding Proteins<br /> * Diastole<br /> * Female<br /> * Genotype<br /> * Humans<br /> * Laser-Doppler Flowmetry<br /> * Male<br /> * Middle Aged<br /> * Mitral Valve<br /> * Polymorphism, Genetic<br /> * Ventricular Function, Left<br /> <br /> |full-text-url=https://sci-hub.do/10.1097/HJH.0b013e3282f97dcd<br /> }}</div>

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