https://transhumanist.ru/index.php?action=history&feed=atom&title=ADCY5ADCY5 - История изменений2026-06-08T03:39:07ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=ADCY5&diff=5297&oldid=prevOdysseusBot: Новая страница: «Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) ==Publications== {{medline-entry |title=...»2021-05-12T13:38:05Z<p>Новая страница: «Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) ==Publications== {{medline-entry |title=...»</p>
<p><b>Новая страница</b></p><div>Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5)<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23020224<br />
|abstract=β-adrenoceptors are the common pharmacological targets for the treatment of cardiovascular diseases and asthma. Genetic modifications of β-adrenergic system in engineered mice affect their lifespan. Here, we tested whether genes encoding for key components of the β-adrenergic signaling pathway are associated with human longevity. We performed a 10-year follow-up study of the Chinese longitudinal healthy longevity survey. The Han Chinese population in this study consisted of 963 long-lived and 1028 geography-matched young individuals. Sixteen SNPs from [[ADRB1]], [[ADRB2]], [[ADCY5]], [[ADCY6]], and [[MAPK1]] were selected and genotyped. Two SNPs, rs1042718 (C/A) and rs1042719 (G/C), of [[ADRB2]] in linkage disequilibrium (D' = 1.0; r2 = 0.67) were found to be associated with enhanced longevity in men in two geographically isolated populations. Bonferroni-corrected P-values in a combined analysis were 0.00053-0.010. Men with haplotype A-C showed an increased probability to become centenarians (the frequency of A-C in long-lived and young individuals are 0.332 and 0.250, respectively, OR = 1.49, CI 95% = 1.17-1.88, P = 0.0007), in contrast to those with haplotype C-G (the frequency of C-G in long-lived and young individuals are 0.523 and 0.635, respectively, OR = 0.63, CI 95% = 0.51-0.78, P = 0.000018). The permuted P-values were 0.00005 and 0.0009, respectively. [[ADRB2]] encodes the β2-adrenergic receptor; the haplotype A-C markedly reduced its translational efficiency compared with C-G (P = 0.002) in transfected HEK293 cells. Thus, our data indicate that enhanced production of β2-adrenergic receptors caused by genetic variants is inversely associated with human lifespan.<br />
|mesh-terms=* Adenylyl Cyclases<br />
* Aged, 80 and over<br />
* Aging<br />
* Asian Continental Ancestry Group<br />
* Case-Control Studies<br />
* Female<br />
* Follow-Up Studies<br />
* Genes, Reporter<br />
* HEK293 Cells<br />
* Haplotypes<br />
* Humans<br />
* Linkage Disequilibrium<br />
* Longevity<br />
* Luciferases, Renilla<br />
* Male<br />
* Mitogen-Activated Protein Kinase 1<br />
* Polymorphism, Single Nucleotide<br />
* Protein Biosynthesis<br />
* Receptors, Adrenergic, beta-1<br />
* Receptors, Adrenergic, beta-2<br />
* Surveys and Questionnaires<br />
* Transfection<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633790<br />
}}</div>OdysseusBot