https://transhumanist.ru/index.php?action=history&feed=atom&title=ADAMTS18 2026-05-16T05:30:54Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ADAMTS18&diff=5095&oldid=prev 2021-05-12T13:29:00Z

<p>Новая страница: «A disintegrin and metalloproteinase with thrombospondin motifs 18 precursor (EC 3.4.24.-) (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18) [ADAMTS21] ==Publications== {{med...»</p> <p><b>Новая страница</b></p><div>A disintegrin and metalloproteinase with thrombospondin motifs 18 precursor (EC 3.4.24.-) (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18) [ADAMTS21]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=A genome-wide search for genetic influences and biological pathways related to the brain&#039;s white matter integrity.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22425255<br /> |abstract=A genome-wide search for genetic variants influencing the brain&#039;s white matter integrity in old age was conducted in the Lothian Birth Cohort 1936 (LBC1936). At ∼73 years of age, members of the LBC1936 underwent diffusion MRI, from which 12 white matter tracts were segmented using quantitative tractography, and tract-averaged water diffusion parameters were determined (n = 668). A global measure of white matter tract integrity, g(FA), derived from principal components analysis of tract-averaged fractional anisotropy measurements, accounted for 38.6% of the individual differences across the 12 white matter tracts. A genome-wide search was performed with g(FA) on 535 individuals with 542,050 single nucleotide polymorphisms (SNPs). No single SNP association was genome-wide significant (all p &gt; 5 × 10(-8)). There was genome-wide suggestive evidence for two SNPs, one in [[ADAMTS18]] (p = 1.65 × 10(-6)), which is related to tumor suppression and hemostasis, and another in LOC388630 (p = 5.08 × 10(-6)), which is of unknown function. Although no gene passed correction for multiple comparisons in single gene-based testing, biological pathways analysis suggested evidence for an over-representation of neuronal transmission and cell adhesion pathways relating to g(FA).<br /> |mesh-terms=* Aged<br /> * Aging<br /> * Female<br /> * Genome, Human<br /> * Humans<br /> * Male<br /> * Nerve Fibers, Myelinated<br /> * Nerve Tissue Proteins<br /> * Polymorphism, Single Nucleotide<br /> <br /> |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2012.02.003<br /> }}</div>

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