https://transhumanist.ru/index.php?action=history&feed=atom&title=ADAM9 2026-06-11T12:36:02Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ADAM9&diff=4779&oldid=prev 2021-04-29T19:34:35Z

<p>Новая страница: «Disintegrin and metalloproteinase domain-containing protein 9 precursor (EC 3.4.24.-) (ADAM 9) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprot...»</p> <p><b>Новая страница</b></p><div>Disintegrin and metalloproteinase domain-containing protein 9 precursor (EC 3.4.24.-) (ADAM 9) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) [KIAA0021] [MCMP] [MDC9] [MLTNG]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[The effect of PNS on the content and activity of alpha-secretase in the brains of SAMP8 mice with alzheimer&#039;s disease].<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23627094<br /> |abstract=To explore the effects of PNS on the content and activity of alpha-secretase in the brains of SAMP8 mice with Alzheimer&#039;s disease. SAMP8 mice were randomly divided into four groups: PNS high-dosage group, PNS low-dosage group, huperzine A group and control group. The high-dosage group and low-dosage group were treated with 200 and 100 mg/kg PNS respectively per day and the huperzine A group was treated with 0.3 mg/kg huperzine A per day, all by intragastric administration for 8 consecutive weeks. The same volume of double distilled water was given to the control group. The activity of a-secretase was assayed by direct immunofluorescent method(DIF). Western blot was used to detect the content of alpha-secretase including [[ADAM9]], [[ADAM10]] and [[ADAM17]] proteins. The Relative Fluorescence Units (RFU) of PNS high-dosage and low-dosage groups were higher than that of control group (P &lt; 0.01). The results of western blot showed that the level of [[ADAM9]] protein expression in PNS high-dosage, low-dosage and huperzine A groups was significantly higher than that of control group (P &lt; 0.05) while the levels of [[ADAM10]] protein expression in PNS high-dosage, low-dosage and huperzine A groups was significantly lower than that of control group (P &lt; 0.05), while level of [[ADAM17]] of huperzine A group was higher than that of control group (P &lt; 0.05). PNS can increase activity of alpha-secretase in the brain of SAMP8 mouse via increasing the level of [[ADAM9]] protein expression.<br /> |mesh-terms=* ADAM Proteins<br /> * ADAM10 Protein<br /> * ADAM17 Protein<br /> * Aging<br /> * Alzheimer Disease<br /> * Amyloid Precursor Protein Secretases<br /> * Amyloid beta-Protein Precursor<br /> * Animals<br /> * Blotting, Western<br /> * Brain<br /> * Disease Models, Animal<br /> * Female<br /> * Gene Expression Regulation, Enzymologic<br /> * Membrane Proteins<br /> * Mice<br /> * Panax notoginseng<br /> * Random Allocation<br /> * Saponins<br /> <br /> <br /> }}</div>

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