https://transhumanist.ru/index.php?action=history&feed=atom&title=ADAM33 2026-09-01T21:21:59Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ADAM33&diff=5718&oldid=prev 2021-05-12T13:56:41Z

<p>Новая страница: «Disintegrin and metalloproteinase domain-containing protein 33 precursor (EC 3.4.24.-) (ADAM 33) [C20orf153] [UNQ873/PRO1891] ==Publications== {{medline-entry |...»</p> <p><b>Новая страница</b></p><div>Disintegrin and metalloproteinase domain-containing protein 33 precursor (EC 3.4.24.-) (ADAM 33) [C20orf153] [UNQ873/PRO1891]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Polymorphisms of the [[ADAM33]] gene are associated with accelerated lung function decline in asthma.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/15144468<br /> |abstract=Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper-responsiveness due to airway inflammation and remodelling. The [[ADAM33]] gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling. To investigate whether polymorphisms of the [[ADAM33]] gene are associated with accelerated lung function decline in patients with asthma. In a cohort of 200 asthma patients followed over 20 years, eight single nucleotide polymorphisms of the [[ADAM33]] gene were analysed to estimate their effect on annual FEV(1) decline. The rare allele of the S_2 polymorphism was significantly associated with excess decline in FEV(1) (P&lt;0.05). These findings suggest that a variant in [[ADAM33]] is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling.<br /> |mesh-terms=* ADAM Proteins<br /> * Adolescent<br /> * Adult<br /> * Aging<br /> * Asthma<br /> * Disease Progression<br /> * Forced Expiratory Volume<br /> * Genetic Predisposition to Disease<br /> * Humans<br /> * Longitudinal Studies<br /> * Lung<br /> * Metalloendopeptidases<br /> * Polymorphism, Genetic<br /> * Polymorphism, Single Nucleotide<br /> <br /> |full-text-url=https://sci-hub.do/10.1111/j.1365-2222.2004.1938.x<br /> }}</div>

OdysseusBot