https://transhumanist.ru/index.php?action=history&feed=atom&title=ACTA2ACTA2 - История изменений2026-04-06T23:51:07ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=ACTA2&diff=5802&oldid=prevOdysseusBot: Новая страница: «Actin, aortic smooth muscle precursor (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Contains: Actin, aortic smooth muscle, intermediate form] [ACTSA]...»2021-05-12T14:52:52Z<p>Новая страница: «Actin, aortic smooth muscle precursor (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Contains: Actin, aortic smooth muscle, intermediate form] [ACTSA]...»</p>
<p><b>Новая страница</b></p><div>Actin, aortic smooth muscle precursor (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Contains: Actin, aortic smooth muscle, intermediate form] [ACTSA] [ACTVS] [GIG46]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Tissue Taurine Depletion Induces Profibrotic Pattern of Gene Expression and Causes Aging-Related Cardiac Fibrosis in Heart in Mice.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30270325<br />
|abstract=Dietary taurine deficiency results in dilated cardiomyopathy in cats while in mice taurine deficiency produced by knocking out the taurine transporter (TauT) gene leads to a reduction in cardiac function with advancing age. The present study elucidated the involvement of cardiac fibrosis in the aging-dependent cardiac disorder of the TauT-knockout (TauTKO) mouse. Old (18-24-month-old) TauTKO mice, but not young (3-5-month-old) mice, exhibit cardiac fibrosis. Transcriptome microarray analysis revealed an increase in pro-fibrotic genes, such as [[S100A4]], [[ACTA2]] and CTGF, in both young and old TauTKO hearts. Based on transcriptome-pathway analysis the genes involved in "organization of extracellular matrix," such as [[LGALS3]], are enriched in old TauTKO hearts compared to old wild-type hearts, suggesting the contribution of these genes to fibrosis. In conclusion, taurine depletion predisposes the heart to fibrosis, which leads to cardiac fibrosis upon aging.<br />
|mesh-terms=* Actins<br />
* Aging<br />
* Animals<br />
* Connective Tissue Growth Factor<br />
* Fibrosis<br />
* Galectin 3<br />
* Gene Expression<br />
* Heart<br />
* Heart Diseases<br />
* Mice, Knockout<br />
* Myocardium<br />
* S100 Calcium-Binding Protein A4<br />
* Taurine<br />
* Transcriptome<br />
|keywords=* cardiac fibrosis<br />
* cardiomyopathy<br />
* knockout mouse<br />
* taurine depletion<br />
|full-text-url=https://sci-hub.do/10.1248/bpb.b18-00217<br />
}}</div>OdysseusBot