https://transhumanist.ru/index.php?action=history&feed=atom&title=ACMSDACMSD - История изменений2026-04-08T05:13:29ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=ACMSD&diff=3978&oldid=prevOdysseusBot: Новая страница: «2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) ==Publications== {{medline-entry |title=De novo NAD synthesis enh...»2021-04-29T18:54:38Z<p>Новая страница: «2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) ==Publications== {{medline-entry |title=De novo NAD synthesis enh...»</p>
<p><b>Новая страница</b></p><div>2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase)<br />
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==Publications==<br />
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{{medline-entry<br />
|title=De novo NAD synthesis enhances mitochondrial function and improves health.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30356218<br />
|abstract=Nicotinamide adenine dinucleotide (NAD ) is a co-substrate for several enzymes, including the sirtuin family of NAD -dependent protein deacylases. Beneficial effects of increased NAD levels and sirtuin activation on mitochondrial homeostasis, organismal metabolism and lifespan have been established across species. Here we show that α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase ([[ACMSD]]), the enzyme that limits spontaneous cyclization of α-amino-β-carboxymuconate-ε-semialdehyde in the de novo NAD synthesis pathway, controls cellular NAD levels via an evolutionarily conserved mechanism in Caenorhabditis elegans and mouse. Genetic and pharmacological inhibition of [[ACMSD]] boosts de novo NAD synthesis and sirtuin 1 activity, ultimately enhancing mitochondrial function. We also characterize two potent and selective inhibitors of [[ACMSD]]. Because expression of [[ACMSD]] is largely restricted to kidney and liver, these inhibitors may have therapeutic potential for protection of these tissues from injury. In summary, we identify [[ACMSD]] as a key modulator of cellular NAD levels, sirtuin activity and mitochondrial homeostasis in kidney and liver.<br />
|mesh-terms=* Animals<br />
* Caenorhabditis elegans<br />
* Carboxy-Lyases<br />
* Cell Line<br />
* Choline<br />
* Conserved Sequence<br />
* Disease Models, Animal<br />
* Evolution, Molecular<br />
* Female<br />
* Gene Knockdown Techniques<br />
* Health<br />
* Hepatocytes<br />
* Homeostasis<br />
* Humans<br />
* Kidney<br />
* Liver<br />
* Longevity<br />
* Male<br />
* Methionine<br />
* Mice<br />
* Mice, Inbred C57BL<br />
* Mitochondria<br />
* NAD<br />
* Non-alcoholic Fatty Liver Disease<br />
* Rats<br />
* Sirtuins<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448761<br />
}}</div>OdysseusBot