https://transhumanist.ru/index.php?action=history&feed=atom&title=ACAD9 2026-04-19T22:55:21Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ACAD9&diff=5789&oldid=prev 2021-05-12T14:51:41Z

<p>Новая страница: «Complex I assembly factor ACAD9, mitochondrial precursor (Acyl-CoA dehydrogenase family member 9) (EC 1.3.8.-) (ACAD-9) ==Publications== {{medline-entry |title=...»</p> <p><b>Новая страница</b></p><div>Complex I assembly factor ACAD9, mitochondrial precursor (Acyl-CoA dehydrogenase family member 9) (EC 1.3.8.-) (ACAD-9)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29540318<br /> |abstract=Assembly of complex I of the mitochondrial respiratory chain (MRC) requires not only structural subunits for electron transport, but also assembly factors. In the nematode Caenorhabditis elegans, NUAF-1 and NUAF-3 are the only two assembly factors that have been characterized. In this study, we identify ACDH-12 as an assembly factor of the respiratory complex I. We demonstrate for the first time that a deficiency of ACDH-12 affects the formation and function of complex I. RNAi knockdown of acdh-12 also shortens lifespan and decreases fecundity. Although ACDH-12 has long been recognized as a very long-chain acyl-CoA dehydrogenase (VLCAD), the knockdown nematodes did not exhibit any change in body fat content. We suggested that in Caenorhabditis elegans, ACDH-12 is required for the assembly of the respiratory complex I, but may not be crucial to fatty acid oxidation. Interestingly, sequence analysis shows high homology between ACDH-12 and the human [[ACAD9]], a protein that has initially been identified as a VLCAD, but later found to also be involved in the assembly of complex I in human.<br /> |mesh-terms=* Animals<br /> * Caenorhabditis elegans<br /> * Caenorhabditis elegans Proteins<br /> * Electron Transport Complex I<br /> * Fertility<br /> * Gene Knockdown Techniques<br /> * Longevity<br /> * Mitochondria<br /> * Mitochondrial Proteins<br /> * Protein Multimerization<br /> |keywords=* ACAD9<br /> * ACDH-12<br /> * C. elegans<br /> * Complex I assembly factor<br /> * Very long-chain acyl-CoA dehydrogenase<br /> |full-text-url=https://sci-hub.do/10.1016/j.mito.2018.02.010<br /> }}</div>

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