https://transhumanist.ru/index.php?action=history&feed=atom&title=ABLIM3 2026-04-21T02:15:04Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ABLIM3&diff=4436&oldid=prev 2021-04-29T19:18:01Z

<p>Новая страница: «Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) [KIAA0843] [HMFN1661] ==Publications== {{medline-entry |title=Dentate granule...»</p> <p><b>Новая страница</b></p><div>Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) [KIAA0843] [HMFN1661]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29529016<br /> |abstract=Memories become less precise and generalized over time as memory traces reorganize in hippocampal-cortical networks. Increased time-dependent loss of memory precision is characterized by an overgeneralization of fear in individuals with post-traumatic stress disorder (PTSD) or age-related cognitive impairments. In the hippocampal dentate gyrus (DG), memories are thought to be encoded by so-called &#039;engram-bearing&#039; dentate granule cells (eDGCs). Here we show, using rodents, that contextual fear conditioning increases connectivity between eDGCs and inhibitory interneurons (INs) in the downstream hippocampal [[CA3]] region. We identify actin-binding LIM protein 3 ([[ABLIM3]]) as a mossy-fiber-terminal-localized cytoskeletal factor whose levels decrease after learning. Downregulation of [[ABLIM3]] expression in DGCs was sufficient to increase connectivity with [[CA3]] stratum lucidum INs (SLINs), promote parvalbumin (PV)-expressing SLIN activation, enhance feedforward inhibition onto [[CA3]] and maintain a fear memory engram in the DG over time. Furthermore, downregulation of [[ABLIM3]] expression in DGCs conferred conditioned context-specific reactivation of memory traces in hippocampal-cortical and amygdalar networks and decreased fear memory generalization at remote (i.e., distal) time points. Consistent with the observation of age-related hyperactivity of [[CA3]], learning failed to increase DGC-SLIN connectivity in 17-month-old mice, whereas downregulation of [[ABLIM3]] expression was sufficient to restore DGC-SLIN connectivity, increase PV SLIN activation and improve the precision of remote memories. These studies exemplify a connectivity-based strategy that targets a molecular brake of feedforward inhibition in DG-[[CA3]] and may be harnessed to decrease time-dependent memory generalization in individuals with PTSD and improve memory precision in aging individuals.<br /> |mesh-terms=* Aging<br /> * Amygdala<br /> * Animals<br /> * CA3 Region, Hippocampal<br /> * Dentate Gyrus<br /> * Down-Regulation<br /> * Excitatory Postsynaptic Potentials<br /> * Fear<br /> * Female<br /> * Generalization, Response<br /> * HEK293 Cells<br /> * Humans<br /> * Interneurons<br /> * LIM Domain Proteins<br /> * Memory, Long-Term<br /> * Mice, Inbred C57BL<br /> * Microfilament Proteins<br /> * Neural Inhibition<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893385<br /> }}</div>

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