https://transhumanist.ru/index.php?action=history&feed=atom&title=ABCC5ABCC5 - История изменений2026-04-12T06:58:48ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=ABCC5&diff=5747&oldid=prevOdysseusBot: Новая страница: «Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11) [MRP5...»2021-05-12T13:57:58Z<p>Новая страница: «Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11) [MRP5...»</p>
<p><b>Новая страница</b></p><div>Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11) [MRP5]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Bruch membrane aging alters the gene expression profile of human retinal pigment epithelium.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16500769<br />
|abstract=We investigated the effects of age-related changes within the Bruch membrane on the gene expression profile of the [[RPE]]. Immortalized human A[[RPE]]-19 cells were seeded onto acellular human Bruch membrane from younger and older donors and harvested 72 hr later; total RNA was isolated and the gene expression profile was determined using the Affymetrix Human Genome U95A gene chip. Twelve genes were upregulated and 8 genes were downregulated with Bruch membrane aging; RT-PCR confirms that Bruch membrane aging upregulates genes in [[RPE]] cells encoding for transforming growth factor alpha and downregulates genes for vitronectin and the membrane transporter [[ABCC5]]. The role of these changes in the pathogenesis of age-related diseases such as macular degeneration remains to be elucidated.<br />
|mesh-terms=* Adult<br />
* Aged<br />
* Aged, 80 and over<br />
* Aging<br />
* Bruch Membrane<br />
* Cell Line<br />
* Eye Proteins<br />
* Female<br />
* Gene Expression<br />
* Gene Expression Profiling<br />
* Humans<br />
* Male<br />
* Middle Aged<br />
* Oligonucleotide Array Sequence Analysis<br />
* Pigment Epithelium of Eye<br />
* RNA<br />
* RNA, Messenger<br />
* Reverse Transcriptase Polymerase Chain Reaction<br />
* Up-Regulation<br />
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|full-text-url=https://sci-hub.do/10.1080/02713680500514628<br />
}}</div>OdysseusBot