https://transhumanist.ru/index.php?action=history&feed=atom&title=ABCA2 2026-04-18T00:27:41Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ABCA2&diff=5412&oldid=prev 2021-05-12T13:42:51Z

<p>Новая страница: «ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) [ABC2] [KIAA1062] ==Publications== {{medli...»</p> <p><b>Новая страница</b></p><div>ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) [ABC2] [KIAA1062]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Expression of [[ABCA2]] protein in both non-myelin-forming and myelin-forming Schwann cells in the rodent peripheral nerve.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17240058<br /> |abstract=We previously reported that [[ABCA2]], of the A subclass of the ATP-binding cassette (ABC) transporter superfamily, is expressed in mature oligodendrocytes and Schwann cells, the cells responsible for myelination in the brain and the peripheral nerve, respectively. However, unidentified cells expressing [[ABCA2]] also were found. Here, we provide evidence for the expression of [[ABCA2]] in the rodent sciatic nerve not only in Schwann cells, which express the Schwann cell marker S100beta and a zinc finger transcription factor Krox20 (a marker for myelin-forming Schwann cells), but also in Krox20-negative cells, which express glial fibrillary acidic protein (GFAP), a cell adhesion molecule L1, and S100beta weekly. We also analyzed developmental changes in [[ABCA2]] expression in Schwann cells. The expression of [[ABCA2]] in Krox20 /S100beta Schwann cells was found initially in rat facial nerve at postnatal day (PD) 8, in half (52.4%) of the cells showing myelinization at PD 14, and in all of the cells in the adult stage. These results demonstrate that [[ABCA2]] is expressed in non-myelin-forming as well as in myelin-forming Schwann cells, and that [[ABCA2]] may be involved in transport of a substance associated with cellular maturation rather than initial myelin formation in both types of Schwann cells.<br /> |mesh-terms=* ATP-Binding Cassette Transporters<br /> * Aging<br /> * Animals<br /> * Animals, Newborn<br /> * Biomarkers<br /> * Cell Differentiation<br /> * Early Growth Response Protein 1<br /> * Facial Nerve<br /> * Glial Fibrillary Acidic Protein<br /> * Mice<br /> * Mice, Inbred C57BL<br /> * Myelin Sheath<br /> * Nerve Fibers, Myelinated<br /> * Nerve Growth Factors<br /> * Neural Cell Adhesion Molecule L1<br /> * Peripheral Nerves<br /> * Rats<br /> * Rats, Sprague-Dawley<br /> * S100 Calcium Binding Protein beta Subunit<br /> * S100 Proteins<br /> * Schwann Cells<br /> * Sciatic Nerve<br /> <br /> |full-text-url=https://sci-hub.do/10.1016/j.neulet.2006.12.028<br /> }}<br /> {{medline-entry<br /> |title=Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16181433<br /> |abstract=Using in situ hybridization for the mouse brain, we analyzed developmental changes in gene expression for the ATP-binding cassette (ABC) transporter subfamilies [[ABCA1]]-4 and 7, and [[ABCG1]], 2, 4, 5 and 8. In the embryonic brains, [[ABCA1]] and A7 were highly expressed in the ventricular (or germinal) zone, whereas [[ABCA2]], A3 and G4 were enriched in the mantle (or differentiating) zone. At the postnatal stages, [[ABCA1]] was detected in both the gray and white matter and in the choroid plexus. On the other hand, [[ABCA2]], A3 and A7 were distributed in the gray matter. In addition, marked up-regulation of [[ABCA2]] occurred in the white matter at 14 days-of-age when various myelin protein genes are known to be up-regulated. In marked contrast, [[ABCA4]] was selective to the choroid plexus throughout development. [[ABCG1]] was expressed in both the gray and white matters, whereas [[ABCG4]] was confined to the gray matter. [[ABCG2]] was diffusely and weakly detected throughout the brain at all stages examined. Immunohistochemistry of [[ABCG2]] showed its preferential expression on the luminal membrane of brain capillaries. Expression signals for [[ABCG5]] and G8 were barely detected at any stages. The distinct spatio-temporal expressions of individual ABCA and G transporters may reflect their distinct cellular expressions in the developing and adult brains, presumably, to regulate and maintain lipid homeostasis in the brain.<br /> |mesh-terms=* ATP-Binding Cassette Transporters<br /> * Aging<br /> * Animals<br /> * Animals, Newborn<br /> * Brain<br /> * Embryo, Mammalian<br /> * Immunohistochemistry<br /> * In Situ Hybridization<br /> * Mice<br /> * Mice, Inbred C57BL<br /> * Tissue Distribution<br /> <br /> |full-text-url=https://sci-hub.do/10.1111/j.1471-4159.2005.03369.x<br /> }}</div>

OdysseusBot