Редактирование: UVSSA

UV-stimulated scaffold protein A [KIAA1530]

==Publications==

{{medline-entry
|title=A C. elegans homolog for the UV-hypersensitivity syndrome disease gene [[UVSSA]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27043179
|abstract=The transcription-coupled repair pathway (TC-NER) plays a vital role in removing transcription-blocking DNA lesions, particularly UV-induced damage. Clinical symptoms of the two TC-NER-deficiency syndromes, Cockayne syndrome (CS) and UV-hypersensitivity syndrome (UVSS) are dissimilar and the underlying molecular mechanism causing this difference in disease pathology is not yet clearly understood. UV-stimulated scaffold protein A ([[UVSSA]]) has been identified recently as a new causal gene for UVSS. Here we describe a functional homolog of the human [[UVSSA]] gene in the nematode Caenorhabditis elegans, uvs-1 ([[UVSSA]]-like-1). Mutations in uvs-1 render the animals hypersensitive to UV-B irradiation and transcription-blocking lesion-inducing illudin-M, similar to mutations in TC-NER deficient mutants. Moreover, we demonstrate that TC-NER factors including UVS-1 are required for the survival of the adult animals after UV-treatment.
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Carrier Proteins
* DNA Repair
* Humans
* Longevity
* Mutation
* Oxidative Stress
* Polycyclic Sesquiterpenes
* Sequence Homology, Nucleic Acid
* Sesquiterpenes
* Transcription, Genetic
* Ultraviolet Rays
|keywords=* C. elegans
* Cockayne syndrome
* DNA damage
* Nucleotide excision repair
* UV-hypersensitivity syndrome
* Ultraviolet light
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886821
}}