Редактирование: TFG

Protein TFG (TRK-fused gene protein)

==Publications==

{{medline-entry
|title=[[TFG]]-maintaining stability of overlooked [[FANCD2]] confers early DNA-damage response.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33099537
|abstract=Emerging Fanconi Anemia (FA) signaling in the field of cancer research annotates the extreme importance of its center player, Fanconi Anemia complementation group D2 ([[FANCD2]]) in protecting human cells from going awry. However, a previously-unrecognized form of [[FANCD2]], namely [[FANCD2]]-V2, is understudied. We report TRK-Fused Gene ([[TFG]]) is critical for roles played by [[FANCD2]]-V2 in early responses to DNA damage, but not for [[FANCD2]]-V1, the long-known form of [[FANCD2]]. [[FANCD2]]-V2 forms nuclear foci upon DNA damage, and both its focus appearance and disappearance are earlier than [[FANCD2]]-V1. The amino acid/aa 5-100 of [[TFG]] and the aa1437-1442 of [[FANCD2]]-V2 were identified to contribute to their interaction, which maintains the steady-state level of [[FANCD2]]-V2 protein. [[TFG]]Δaa5-100 or [[FANCD2]]-V2Δaa1437-1442-carrying cells could not show timely focus formation of [[FANCD2]]-V2 upon DNA damage and gained carcinogenicity over time. This study provides a previously-unknown key to unlock in-depth insights into maintaining genome stability, fostering translational studies on preventing, diagnosing and/or treating related diseases.

|keywords=* DNA damage response
* FANCD2
* TFG
* aging and cancer
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655164
}}