Редактирование: TAB2

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) [KIAA0733] [MAP3K7IP2]

==Publications==

{{medline-entry
|title=Expression analysis of the [[TAB2]] protein in adult mouse tissues.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17406806
|abstract=The Interleukin-1 (IL-1) signaling component TAK1 binding protein 2 ([[TAB2]]) plays a role in activating the NFkappaB and JNK signaling pathways. Additionally, [[TAB2]] functions in the nucleus as a repressor of NFkappaB-mediated gene regulation. To obtain insight into the function of [[TAB2]] in the adult mouse, we analyzed the in vivo [[TAB2]] expression pattern. Cell lines and adult mouse tissues were analyzed for [[TAB2]] protein expression and localization. Immunohistochemical staining for [[TAB2]] protein revealed expression in the vascular endothelium of most tissues, hematopoietic cells and brain cells. While [[TAB2]] is localized in both the nucleus and the cytoplasm in cell lines, cytoplasmic localization predominates in hematopoietic tissues in vivo. The [[TAB2]] expression pattern shows striking similarities with previously reported IL-1 receptor expression and NFkappaB activation patterns, suggesting that [[TAB2]] in vivo is playing a role in these signaling pathways.
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Aging
* Animals
* Bone Marrow
* Cell Line
* Cell Nucleus
* Cells, Cultured
* Cricetinae
* Cytoplasm
* Gene Expression Regulation
* Isoenzymes
* MAP Kinase Kinase Kinases
* Mice
* Organ Specificity
* RNA, Messenger
* Recombinant Proteins
* Spleen

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770139
}}