Редактирование: SUSD2

Sushi domain-containing protein 2 precursor

==Publications==

{{medline-entry
|title=Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33271899
|abstract=Rare perivascular mesenchymal stromal cells ([[MSC]]s) with therapeutic properties have been identified in many tissues. Their rarity necessitates extensive in vitro expansion, resulting in spontaneous differentiation, cellular senescence and apoptosis, producing therapeutic products with variable quality and decreased potency. We previously demonstrated that A83-01, a transforming growth factor beta (TGF-β) receptor inhibitor, maintained clonogenicity and promoted the potency of culture-expanded premenopausal endometrial [[MSC]]s using functional assays and whole-transcriptome sequencing. Here, we compared the effects of A83-01 on [[MSC]]s derived from postmenopausal endometrium, menstrual blood, placenta decidua-basalis, bone marrow and adipose tissue. Sushi-domain-containing-2 ([[SUSD2]] ) and [[CD34]] CD31 CD45  [[MSC]]s were isolated. Expanded [[MSC]]s were cultured with or without A83-01 for 7 days and assessed for [[MSC]] properties. [[SUSD2]] identified perivascular cells in the placental decidua-basalis, and their maternal origin was validated. A83-01 promoted [[MSC]] proliferation from all sources except bone marrow and only increased [[SUSD2]] expression and prevented apoptosis in [[MSC]]s from endometrial-derived tissues. A83-01 only improved the cloning efficiency of postmenopausal endometrial [[MSC]]s (e[[MSC]]s), and expanded adipose tissue [[MSC]]s (ad[[MSC]]s) underwent significant senescence, which was mitigated by A83-01. [[MSC]]s derived from bone marrow (bm[[MSC]]s) were highly apoptotic, but A83-01 was without effect. A83-01 maintained the function and phenotype in [[MSC]]s cultured from endometrial, but not other, tissues. Our results also demonstrated that cellular [[SUSD2]] expression directly correlates with the functional phenotype.

|keywords=* SUSD2
* adipose tissue
* apoptosis
* bone marrow
* clonogenicity
* endometrium
* menstrual fluid
* perivascular mesenchymal stromal cells
* placenta
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712261
}}