Редактирование: SHOX

Short stature homeobox protein (Pseudoautosomal homeobox-containing osteogenic protein) (Short stature homeobox-containing protein) [PHOG]

==Publications==

{{medline-entry
|title=Statural growth in 31 Japanese patients with [[SHOX]] haploinsufficiency: support for a disadvantageous effect of gonadal estrogens.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/15118270
|abstract=Although gonadal estrogens are known to facilitate the development of skeletal lesion in [[SHOX]] haploinsufficiency, controversy exists as to whether gonadal estrogens are disadvantageous to pubertal growth. To clarify this matter, we analyzed growth pattern in 31 Japanese patients with a normal karyotype and molecularly confirmed [[SHOX]] haploinsufficiency. The mean height SD score at the diagnosis of [[SHOX]] haploinsufficiency was similar between patients identified in childhood and those identified in adulthood (-2.7  /- 0.8 [n = 15] vs. -2.4  /- 0.7 [n = 16], P = 0.36), and was significantly lower in patients identified by the studies for short stature than in those ascertained by the familial studies of the probands both in childhood (-3.0  /- 0.6 [n = 11] vs. -1.8  /- 0.5 [n = 4], P = 0.0051) and in adulthood (-3.0  /- 0.9 [n = 5] vs. -2.2  /- 0.5 [n = 11], P = 0.040). Analysis of longitudinal paired growth data obtained in seven females showed a significantly different mean height SD score between childhood and adulthood (-2.3  /- 0.5 vs. -2.9  /- 0.8, P = 0.0060). The results imply that gonadal estrogens have a deleterious effect on pubertal growth in [[SHOX]] haploinsufficiency, and that the growth disadvantage is recognizable by longitudinal rather than cross-sectional growth studies.
|mesh-terms=* Adolescent
* Adult
* Aging
* Asian Continental Ancestry Group
* Body Height
* Child
* Estrogens
* Female
* Growth
* Haplotypes
* Homeodomain Proteins
* Humans
* Infant
* Longitudinal Studies
* Male
* Ovary
* Short Stature Homeobox Protein
* Transcription Factors

|full-text-url=https://sci-hub.do/10.1507/endocrj.51.197
}}