Редактирование: SELENOW

Selenoprotein W (SelW) [SELW] [SEPW1]

==Publications==

{{medline-entry
|title=The Thioredoxin-Like Family of Selenoproteins: Implications in Aging and Age-Related Degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30229511
|abstract=The thioredoxin-like (Rdx) family proteins contain four selenoproteins (selenoprotein H, [[SELENOH]]; selenoprotein T, [[SELENOT]]; selenoprotein V, [[SELENOV]]; selenoprotein W, [[SELENOW]]) and a nonselenoprotein Rdx12. They share a CxxU or a CxxC (C, cysteine; x, any amino acid; U, selenocysteine) motif and a stretch of eGxFEI(V) sequence. From the evolutionary perspective, [[SELENOW]] and [[SELENOV]] are clustered together and [[SELENOH]] and [[SELENOT]] are in another branch. Selenoproteins in the Rdx family exhibit tissue- and organelle-specific distribution and are differentially influenced in response to selenium deficiency. While [[SELENOH]] is nucleus-exclusive, [[SELENOT]] resides mainly in endoplasmic reticulum and [[SELENOW]] in cytosol. [[SELENOV]] is expressed essentially only in the testes with unknown cellular localization. [[SELENOH]] and [[SELENOW]] are more sensitive than [[SELENOT]] and [[SELENOV]] to selenium deficiency. While physiological functions of the Rdx family of selenoproteins are not fully understand, results from animal models demonstrated that (1) brain-specific [[SELENOT]] knockout mice are susceptible to 1-methyl-4-phenylpyridinium-induced Parkinson's disease in association with redox imbalance and (2) adult zebrafishes with heterozygous [[SELENOH]] knockout are prone to dimethylbenzanthracene-induced tumorigenesis together with increased DNA damage and oxidative stress. Further animal and human studies are needed to fully understand physiological roles of the Rdx family of selenoproteins in redox regulation, genome maintenance, aging, and age-related degeneration.
|mesh-terms=* Aging
* Animals
* Humans
* Selenium
* Selenoproteins
* Thioredoxins
|keywords=* Selenium
* Selenoprotein H
* Selenoprotein T
* Selenoprotein V
* Selenoprotein W
|full-text-url=https://sci-hub.do/10.1007/s12011-018-1521-9
}}
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