Редактирование: RGS12

Regulator of G-protein signaling 12 (RGS12)

==Publications==

{{medline-entry
|title=[[RGS9]]: a regulator of G-protein signalling with specific expression in rat and mouse striatum.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/9556034
|abstract=A clone of the regulator of G-protein signalling, [[RGS9]], was isolated from a rat striatum-minus-cerebellum-minus-hippocampus subtracted library generated by directional tag polymerase chain reaction subtraction. The full-length cDNA clone encodes a 444 amino acid protein containing an 118 amino acid RGS domain, which corresponds to an evolutionarily conserved domain that is present in all members of the RGS family of proteins. Outside of the homology domain, [[RGS9]] shows more extended similarity to human [[RGS6]] and [[RGS7]], rat [[RGS12]], and the C. elegans protein EGL-10. During embryonic and early postnatal stages of development, two [[RGS9]] transcripts of approximately 1.4 Kb and 1.8 Kb were detected in whole brain. After postnatal day 10, accumulation of the larger transcript increased progressively until adulthood at the expense of the smaller transcript, which was undetectable in the adult. In adult rat brain, the 1.8-Kb [[RGS9]] transcript was detected in the striatum but not in other brain regions or peripheral tissues. In situ hybridization in rat and mouse demonstrates that [[RGS9]] mRNA is expressed predominantly in medium-sized, spiny neurons of the neostriatum and in neurons of the nucleus accumbens and olfactory tubercle. Relatively strong signals were also detected in some hypothalamic nuclei. Its selective expression suggests that [[RGS9]] may play an important role in modulation of the complex signalling pathways of the basal ganglia.
|mesh-terms=* Aging
* Amino Acid Sequence
* Animals
* Base Sequence
* Brain
* Caenorhabditis elegans
* Cloning, Molecular
* Conserved Sequence
* Corpus Striatum
* Evolution, Molecular
* GTP Phosphohydrolases
* GTP-Binding Proteins
* GTPase-Activating Proteins
* Gene Expression Regulation, Developmental
* Gene Library
* Humans
* Mice
* Molecular Sequence Data
* Polymerase Chain Reaction
* Protein Biosynthesis
* Proteins
* RNA, Messenger
* Rats
* Recombinant Proteins
* Sequence Alignment
* Sequence Homology, Amino Acid
* Signal Transduction
* Transcription, Genetic

|full-text-url=https://sci-hub.do/10.1002/(SICI)1097-4547(19980401)52:1<118::AID-JNR11>3.0.CO;2-6
}}