Редактирование: RELN

Reelin precursor (EC 3.4.21.-)

==Publications==

{{medline-entry
|title=Neocortical [[RELN]] promoter methylation increases significantly after puberty.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/19952965
|abstract=Reelin plays a pivotal role in neurodevelopment. Excessive [[RELN]] promoter methylation and/or decreased [[RELN]] gene expression have been described in schizophrenia and autism. We assessed [[RELN]] promoter methylation in post-mortem temporocortical tissue (Brodmann Area 41/42) of three prepuberal and six postpuberal normal individuals. The former display very little or no methylation, whereas most postpuberal individuals are heavily methylated, especially at CpG positions located between -131 and -98 bp (prepuberal vs. postpuberal, P<0.05). Sex hormones thus seemingly boost DNA methylation at the [[RELN]] promoter. This physiological change could significantly contribute to the onset of schizophrenia and the worsening of autistic behaviors, both typically occurring at puberty.
|mesh-terms=* Adolescent
* Adult
* Age of Onset
* Aging
* Autistic Disorder
* Cell Adhesion Molecules, Neuronal
* Child
* Child, Preschool
* CpG Islands
* DNA Methylation
* Epigenesis, Genetic
* Extracellular Matrix Proteins
* Female
* Gene Expression Regulation, Developmental
* Genetic Markers
* Gonadal Steroid Hormones
* Humans
* Male
* Neocortex
* Nerve Tissue Proteins
* Promoter Regions, Genetic
* Puberty
* Schizophrenia
* Serine Endopeptidases
* Temporal Lobe
* Up-Regulation
* Young Adult

|full-text-url=https://sci-hub.do/10.1097/WNR.0b013e328334b343
}}