Редактирование: PPP3R1

Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) [CNA2] [CNB]

==Publications==

{{medline-entry
|title=Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17761791
|abstract=To examine the influence of insulin-like growth factor (IGF) pathway gene polymorphisms on muscle mass and strength responses to strength training (ST), we studied 128 White and Black men and women before and after a 10-wk single-leg knee extension ST program. One-repetition maximum strength, muscle volume (MV) via computed tomography, and muscle quality (MQ) were assessed at baseline and after 10 wk of ST. There was a significant combined [[IGF1]] cytosine adenine (CA) repeat gene effect, which included both the [[IGF1]] CA repeat main effect and [[IGF1]] CA repeat x [[PPP3R1]] insertion-deletion (I/D) gene x gene interaction effect, on the changes in strength (P < 0.01) and MQ (P < 0.05) with ST. There was a trend for a significant gene x gene interaction between [[IGF1]] CA repeat and [[PPP3R1]] I/D for changes in strength (P = 0.07) and MQ (P = 0.06) with ST. The influence of the [[PPP3R1]] A-202C gene polymorphism on change in MV with ST approached significance (P = 0.06). The [[IGF1]] CA repeat polymorphism had a significant influence on the change in strength and MV combined with ST (P < 0.05), whereas the influence of the [[PPP3R1]] I/D polymorphism approached significance (P = 0.08). There were no associations between the [[IGFBP3]] A-202C gene polymorphism and the muscle phenotypic responses to ST. These data suggest that two of the three IGF pathway gene polymorphisms identified in this study influence muscle phenotypic responses to ST in both black and white older men and women.
|mesh-terms=* African Americans
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Calcineurin
* Dinucleotide Repeats
* European Continental Ancestry Group
* Exercise
* Female
* Gene Frequency
* Genotype
* Humans
* Insulin-Like Growth Factor Binding Protein 3
* Insulin-Like Growth Factor Binding Proteins
* Insulin-Like Growth Factor I
* Male
* Middle Aged
* Muscle Contraction
* Muscle Strength
* Muscle, Skeletal
* Phenotype
* Phosphoprotein Phosphatases
* Polymorphism, Genetic
* Promoter Regions, Genetic
* Sex Factors
* Time Factors
* Tomography, X-Ray Computed

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811278
}}