Редактирование: PEBP1

Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Contains: Hippocampal cholinergic neurostimulating peptide (HCNP)] [PBP] [PEBP]

==Publications==

{{medline-entry
|title=[i]Drosophila[/i] [[PEBP1]] inhibits intestinal stem cell aging via suppression of ERK pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29719584
|abstract=The intestine is a high cellular turnover tissue largely dependent on the regenerative function of stem cell throughout life, and a signaling center for the health and viability of organisms. Therefore, better understanding of the mechanisms underlying the regulation of intestinal stem cell (ISC) regenerative potential is essential for the possible intervention of aging process and age-related diseases. [i]Drosophila[/i] midgut is a well-established model system for studying the mechanisms underlying ISC regenerative potential during aging. Here, we report the requirement of [i]Drosophila[/i] phosphatidylethanolamine binding protein 1 ([[PEBP1]]) in ISC regenerative potential. We showed that [[PEBP1]] was strongly expressed in enterocytes (ECs) of guts and its decrease with age and oxidative stress. Furthermore, the downregulation of [[PEBP1]] in ECs accelerates ISC aging, as evidenced by ISC hyper-proliferation, γH2AX accumulation, and centrosome amplification, and intestinal hyperplasia. The decrease in [[PEBP1]] expression was associated with increased extracellular signal-regulated kinase (ERK) activity in ECs. All these phenotypes by EC-specific depletion of [[PEBP1]] were rescued by the concomitant inhibition of ERK signaling. Our findings evidence that the age-related downregulation of [[PEBP1]] in ECs is a novel cause accelerating ISC aging and that [[PEBP1]] is an EC-intrinsic suppressor of epidermal growth factor receptor (EGFR)/ERK signaling. Our study provides molecular insights into the tight regulation of EGFR/ERK signaling in niches for stem cell regenerative potential.

|keywords=* Drosophila
* ERK suppressor
* Gerotarget
* PEBP1
* intestinal stem cell
* stem cell aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915051
}}