Редактирование: PAX4

Paired box protein Pax-4

==Publications==

{{medline-entry
|title=Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25761685
|abstract=Expression levels of genes encoding specific transcription factors and other functionally important proteins vary upon aging of pancreatic and bronchial epithelium cell cultures. The peptides KEDW and AEDL tissue-specifically affect gene expression in pancreatic and bronchial cell cultures, respectively. It is established in this work that the DNA methylation patterns of the [[PDX1]], [[PAX6]], NGN3, [[NKX2-1]], and [[SCGB1A1]] gene promoter regions change upon aging in pancreatic and bronchial cell cultures in correlation with variations in their expression levels. Thus, stable changes in gene expression upon aging of cell cultures could be caused by changes in their promoter methylation patterns. The methylation patterns of the [[PAX4]] gene in pancreatic cells as well as those of the [[FOXA1]], [[SCGB3A2]], and [[SFTPA1]] genes in bronchial cells do not change upon aging and are unaffected by peptides, whereas their expression levels change in both cases. The promoter region of the [[FOXA2]] gene in pancreatic cells contains a small number of methylated CpG sites, their methylation levels being affected by cell culture aging and KEDW, though without any correlation with gene expression levels. The promoter region of the [[FOXA2]] gene is completely unmethylated in bronchial cells irrespective of cell culture age and AEDL action. Changes in promoter methylation might be the cause of age- and peptide-induced variations in expression levels of the [[PDX1]], [[PAX6]], and NGN3 genes in pancreatic cells and [[NKX2-1]] and [[SCGB1A1]] genes in bronchial cells. Expression levels of the [[PAX4]] and [[FOXA2]] genes in pancreatic cells and [[FOXA1]], [[FOXA2]], [[SCGB3A2]], and [[SFTPA1]] genes in bronchial cells seem to be controlled by some other mechanisms. 
|mesh-terms=* Aging
* Cell Line
* Cellular Senescence
* DNA Methylation
* Epigenesis, Genetic
* Gene Expression Regulation
* Humans
* Peptides
* Promoter Regions, Genetic

|full-text-url=https://sci-hub.do/10.1134/S0006297915030062
}}