Редактирование: OPRM1

Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) [MOR1]

==Publications==

{{medline-entry
|title=Variation at the mu-opioid receptor gene ([[OPRM1]]) influences attachment behavior in infant primates.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18378897
|abstract=In a variety of species, development of attachment to a caregiver is crucial for infant survival and partly mediated by the endogenous opioids. Functional mu-opioid receptor gene polymorphisms are present in humans ([[OPRM1]] A118G) and rhesus macaques ([[OPRM1]] C77G). We hypothesized that rhesus infants carrying a gain-of-function [[OPRM1]] 77G allele would experience increased reward during maternal contact and would, therefore, display increased measures of attachment. We collected behavioral data from rhesus macaques (n = 97) during early infancy and at 6 months of age, across four cycles of maternal separation (4 days) and reunion (3 days). Animals were genotyped for the [[OPRM1]] C77G polymorphism, and the effects of this allele on attachment-related behaviors were analyzed. Infants carrying the G allele exhibited higher levels of attachment behavior during early infancy. During prolonged periods of maternal separation, although infant macaques homozygous for the C allele exhibited decreases in their levels of distress vocalization with repeated separation, this response persisted in G allele carriers. The [[OPRM1]] 77G allele also affected social preference during reunion. C/G infants spent increasing amounts of time in social contact with their mothers as a function of repeated separation and were less likely to interact with other individuals in the social group, a pattern not observed among infants with the C/C genotype. These findings suggest a role for [[OPRM1]] variation in the expression of attachment behavior in human subjects, especially as a function of separation from the caregiver.
|mesh-terms=* Aging
* Animals
* Behavior, Animal
* Female
* Genotype
* Humans
* Macaca mulatta
* Male
* Models, Animal
* Mothers
* Object Attachment
* Polymorphism, Genetic
* Receptors, Opioid, mu

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278187
}}