Редактирование: NPAS1

Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5) [BHLHE11] [MOP5] [PASD5]

==Publications==

{{medline-entry
|title=Behavioral and regulatory abnormalities in mice deficient in the [[NPAS1]] and [[NPAS3]] transcription factors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/15347806
|abstract=Laboratory mice bearing inactivating mutations in the genes encoding the [[NPAS1]] and [[NPAS3]] transcription factors have been shown to exhibit a spectrum of behavioral and neurochemical abnormalities. Behavioral abnormalities included diminished startle response, as measured by prepulse inhibition, and impaired social recognition. [[NPAS1]]/[[NPAS3]]-deficient mice also exhibited stereotypic darting behavior at weaning and increased locomotor activity. Immunohistochemical staining assays showed that the [[NPAS1]] and [[NPAS3]] proteins are expressed in inhibitory interneurons and that the viability and anatomical distribution of these neurons are unaffected by the absence of either transcription factor. Adult brain tissues from [[NPAS3]]- and [[NPAS1]]/[[NPAS3]]-deficient mice exhibited a distinct reduction in reelin, a large, secreted protein whose expression has been reported to be attenuated in the postmortem brain tissue of patients with schizophrenia. These observations raise the possibility that a regulatory program controlled in inhibitory interneurons by the [[NPAS1]] and [[NPAS3]] transcription factors may be either substantively or tangentially relevant to psychosis.
|mesh-terms=* Aging
* Animals
* Basic Helix-Loop-Helix Transcription Factors
* Behavior, Animal
* Brain
* Cell Adhesion Molecules, Neuronal
* Extracellular Matrix Proteins
* Gene Deletion
* Gene Expression Profiling
* Homozygote
* Mice
* Mice, Knockout
* Nerve Tissue Proteins
* Neurons
* Serine Endopeptidases
* Social Behavior
* Transcription Factors
* gamma-Aminobutyric Acid

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC518807
}}