Редактирование: NLK

Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1) [LAK1]

==Publications==

{{medline-entry
|title=A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11902125
|abstract=Neuroleukin ([[NLK]]) is a multifunctional protein involved in neuronal growth and survival, cell motility and differentiation, and glucose metabolism. We report herein that hippocampal expression of [[NLK]] and its receptor gp78 is associated with maze learning in rats. First, mRNA levels of [[NLK]] and gp78 were significantly increased in hippocampi of male Fischer-344 rats following training in the Stone T-maze and the Morris water maze. Second, a parallel increase was found in hippocampal [[NLK]] and gp78 proteins after maze learning. Third, [[NLK]] and gp78 mRNA and protein expression in hippocampus was reduced in a group of aged rats that showed more errors during the acquisition of the Stone maze task as compared with young rats. Finally, application of recombinant [[NLK]] to hippocampal neurons significantly enhanced glutamate-induced ion currents, functional molecular changes that have been correlated with learning in vivo. Taken together, our results identify a novel association of hippocampal expression of [[NLK]] and its receptor gp78 with rat maze learning. Interaction of [[NLK]] with gp78 and subsequent signaling may strengthen synaptic mechanisms underlying learning and memory formation.
|mesh-terms=* Aging
* Animals
* Gene Expression
* Glucose-6-Phosphate Isomerase
* Glutamic Acid
* Hippocampus
* Male
* Maze Learning
* Membrane Potentials
* Neuronal Plasticity
* Patch-Clamp Techniques
* Rats
* Rats, Inbred F344
* Receptors, Autocrine Motility Factor
* Receptors, Cytokine
* Receptors, Somatotropin
* Ubiquitin-Protein Ligases

|full-text-url=https://sci-hub.do/10.1046/j.0022-3042.2001.00707.x
}}