Редактирование: MYSM1

Deubiquitinase MYSM1 (EC 3.4.19.-) (2A-DUB) (Myb-like, SWIRM and MPN domain-containing protein 1) [KIAA1915]

==Publications==

{{medline-entry
|title=[[MYSM1]] Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33240758
|abstract=Aging is a universal feature of life that is a major focus of scientific research and a risk factor in many diseases. A comprehensive understanding of the cellular and molecular mechanisms of aging are critical to the prevention of diseases associated with the aging process. Here, it is shown that [[MYSM1]] is a key suppressor of aging and aging-related pathologies. [[MYSM1]] functionally represses cellular senescence and the aging process in human and mice primary cells and in mice organs. [[MYSM1]] mechanistically attenuates the aging process by promoting DNA repair processes. Remarkably, [[MYSM1]] deficiency facilitates the aging process and reduces lifespan, whereas [[MYSM1]] over-expression attenuates the aging process and increases lifespan in mice. The functional role of [[MYSM1]] is demonstrated in suppressing the aging process and prolonging lifespan. [[MYSM1]] is a key suppressor of aging and may act as a potential agent for the prevention of aging and aging-associated diseases.

|keywords=* DNA repair
* Myb‐like, SWIRM, and MPN domains‐containing protein 1 (MYSM1)
* aging
* senescence
* senescence‐associated secretory phenotype (SASP)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675055
}}