Редактирование: MTRR

Methionine synthase reductase (EC 1.16.1.8) (MSR) (Aquacobalamin reductase) (EC 1.16.1.-) (AqCbl reductase)

==Publications==

{{medline-entry
|title=One-carbon metabolism gene polymorphisms are associated with cognitive trajectory among African-American adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31208817
|abstract=The sex-specific link between longitudinal annual rate of cognitive change (LARCC) and polymorphisms in one-carbon metabolism enzymatic genes remains unclear, particularly among African-American adults. We tested associations of 14 single nucleotide polymorphisms (SNPs) from [[MTHFR]], [[MTR]]R, [[MTR]], and SHMT genes and select [[MTHFR]] haplotypes and latent classes (SNPHAP/SNPLC) with LARCC. Up to 797 African-American participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span study (age: 30-64 y, 52% women) had 1.6-1.7 (i.e., 1 or 2) repeated measures (follow-up time, mean = 4.69 y) on 9 cognitive test scores, reflecting verbal and visual memory, verbal fluency, psychomotor speed, attention, and executive function: California Verbal Learning Test-immediate recall (CVLT-List A), CVLT-DFR (delayed free recall), Benton Visual Retention Test (BVRT), Animal Fluency (AF), Digits Span Forward and Backward tests, and Trail Making Test parts A and B (Trails A and B). Multiple linear mixed-effects and multiple linear regression models were conducted. Overall, [[MTHFR]] SNPs rs4846051(A1317G, G>A) and rs1801131(A1298C, G>T) were associated with slower and faster declines on AF, respectively, whereas rs2066462(C1056T, A>G) was related to slower decline on Trails B (executive function). Among men, rs4846051(A1317G, G>A) was linked to faster decline on BVRT (visual memory), whereas rs2066462(C1056T, A>G) and rs9651118(C>T) were associated with slower decline on CVLT-List A and rs9651118(C>T) with faster decline on CVLT-DFR. Among women, a slower decline on the domain "verbal memory/fluency" was observed with rs1801133(C677T, A>G). [[MTHFR]] SNPHAP [rs1801133(C677T, A>G)/rs1801131(A1298C, G>T): GG] was associated with slower decline on AF among women, whereas [[MTHFR]] SNPHAP(AT) was linked with slower decline on CVLT-List A among men but faster decline on "verbal memory/fluency" among women. Similar patterns were observed for [[MTHFR]] SNPLCs. In sum, [[MTHFR]] gene variations can differentially impact longitudinal changes in multiple cognitive domains among African-American adults.
|mesh-terms=* African Americans
* Carbon
* Cognitive Dysfunction
* Humans
* Polymorphism, Genetic
|keywords=* Aging
* Cognitive change
* Genetic polymorphisms
* Haplotypes
* MTHFR
* One-carbon metabolism
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.05.013
}}
{{medline-entry
|title=[Clinical and genetic characteristics of long-livers in Moscow region].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24640693
|abstract=In Moscow region long-livers we have studied distribution of [[LPL]], [[CETP]], [[APOE]], [[F2]], [[F5]], [[F7]], F13, [[FGB]], [[ITGA2]], [[ITGB3]], PAI-1, [[MTHFR]], [[MTRR]], [[HLA-DRB1]], [[HLA-DQA1]], [[HLA-DQB1]] genes polymorphisms, associated with predisposition to age pathology. Long-livers are characterized by favorable course of cardiovascular diseases accompanied by certain genetic factors. We have established that genotype H-H- of [[LPL]], allele epsilon2 of [[APOE]], genotype CC of [[MTHFR]] (677C > T), genotype TC of [[ITGB3]], genotype GA of [[FGB]], [[HLA-DRB1]]*11 positively correlate with longevity.
|mesh-terms=* Aged
* Aged, 80 and over
* Alleles
* Cardiovascular Diseases
* Female
* Gene Frequency
* Genetic Markers
* Genetic Predisposition to Disease
* Genotype
* Humans
* Longevity
* Male
* Moscow
* Polymorphism, Genetic
* Prevalence
* Urban Population


}}