Редактирование: MPG

DNA-3-methyladenine glycosylase precursor (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) [AAG] [ANPG] [MID1]

==Publications==

{{medline-entry
|title=Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26981526
|abstract=The effect of Menoprogen ([[MPG]]) on ovarian granulosa cell ([[GC]]) apoptosis was investigated in vitro and in vivo in an aged rat model of menopause. Intragastric administration of Menoprogen or estradiol valerate to 14-month-old senile female rats for eight weeks increased plasma E2 levels, as well as the weight of both ovarian and uterine tissues. Flow cytometric (FCM) analysis of isolated [[GC]]s from [[MPG]]-treated aged rats showed reductions in the G0/G1 ratio and apoptotic peaks. Isolated [[GC]]s also exhibited an increase in cell size and the number of cytoplastic organelles and intracellular gap junctions, the reappearance of secretory granules, and a lack of apoptotic bodies as determined by TEM. Results from a TdT-mediated dUTP nick end-labeling (TUNEL) assay revealed a reduction in TUNEL-positive [[GC]]s after [[MPG]] treatment. Immunohistochemical analysis showed a downregulation of proapoptotic Bax proteins and an upregulation of antiapoptotic Bcl-2 proteins. The addition of [[MPG]]-medicated serum to the media of cultured [[GC]]s also reduced cadmium chloride-induced apoptosis and downregulated caspase-3 protein expression. This work demonstrates that Menoprogen inhibits [[GC]] apoptosis in aged female rats and thereby increases E2 production. This represents a novel mechanism of action for this herbal medicine in the treatment of menopausal symptoms. 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Disease Models, Animal
* Drugs, Chinese Herbal
* Female
* Granulosa Cells
* Humans
* Menopause
* Ovarian Follicle
* Rats

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769746
}}