Редактирование: LMNB2

Lamin-B2 precursor [LMN2]

==Publications==

{{medline-entry
|title=Physiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear Edge.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27602048
|abstract=Lamins are intermediate filaments that form a complex meshwork at the inner nuclear membrane. Mammalian cells express two types of Lamins, Lamins A/C and Lamins B, encoded by three different genes, [[LMNA]], [[LMNB1]], and [[LMNB2]]. Mutations in the [[LMNA]] gene are associated with a group of phenotypically diverse diseases referred to as laminopathies. Lamins interact with a large number of binding partners including proteins of the nuclear envelope but also chromatin-associated factors. Lamins not only constitute a scaffold for nuclear shape, rigidity and resistance to stress but also contribute to the organization of chromatin and chromosomal domains. We will discuss here the impact of A-type Lamins loss on alterations of chromatin organization and formation of chromatin domains and how disorganization of the lamina contributes to the patho-physiology of premature aging syndromes. 

|keywords=* Lamins
* epigenetics
* nuclear topology
* premature aging
* telomeres
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993774
}}
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