Редактирование: KLF2

Krueppel-like factor 2 (Lung krueppel-like factor) [LKLF]

==Publications==

{{medline-entry
|title=[[KLF2]] induces the senescence of pancreatic cancer cells by cooperating with [[FOXO4]] to upregulate p21.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31866399
|abstract=Pancreatic cancer is one of the most common malignancies in the world. Senescence is frequently observed in the progression of pancreatic cancer. In a previous study, we showed that [[KLF2]] inhibited the growth and migration of pancreatic cancer. However, the mechanisms are not fully understood. In this study, we showed that overexpression of [[KLF2]] induced the senescence of pancreatic cancer cells and inhibited tumorigenesis, and knockdown of [[KLF2]] inhibited senescence and p21 expression. In the molecular mechanism study, [[KLF2]] was found to interact with [[FOXO4]] and cooperated with [[FOXO4]] to induce the expression of p21. Downregulation of p21 and [[FOXO4]] impaired the induction of senescence by [[KLF2]]. Overall, this study revealed the functions and mechanisms of [[KLF2]] in senescence and provided a novel explanation for the suppressive roles of [[KLF2]] in pancreatic cancer.
|mesh-terms=* Animals
* Carcinogenesis
* Cell Cycle Proteins
* Cell Line
* Cells, Cultured
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* Forkhead Transcription Factors
* Kruppel-Like Transcription Factors
* Male
* Mice
* Mice, Nude
* Pancreatic Neoplasms
* Protein Binding
* Up-Regulation
|keywords=* FOXO4
* KLF2
* Pancreatic cancer
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2019.111784
}}