Редактирование: KIR2DL3

Killer cell immunoglobulin-like receptor 2DL3 precursor (CD158 antigen-like family member B2) (KIR-023GB) (Killer inhibitory receptor cl 2-3) (MHC class I NK cell receptor) (NKAT2a) (NKAT2b) (Natural killer-associated transcript 2) (NKAT-2) (p58 natural killer cell receptor clone CL-6) (p58 NK receptor CL-6) (p58.2 MHC class-I-specific NK receptor) (CD158b2 antigen) [CD158B2] [KIRCL23] [NKAT2]

==Publications==

{{medline-entry
|title=Epigenetic regulation of killer immunoglobulin-like receptor expression in T cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/19628706
|abstract=With increasing age, T cells gain expression of killer immunoglobulin-like receptors (KIRs) that transmit negative signals and dampen the immune response. KIR expression is induced in [[CD4]] and CD8 T cells by CpG DNA demethylation suggesting epigenetic control. To define the mechanisms that underlie the age-associated preferential KIR expression in CD8 T cells, we examined [[KIR2DL3]] promoter methylation patterns. With age, CD8 T cells developed a patchy and stochastic promoter demethylation even in cells that did not express the [[KIR2DL3]]-encoded CD158b protein; complete demethylation of the minimal [[KIR2DL3]] promoter was characteristic for CD158b-expressing cells. In contrast, the promoter in [[CD4]] T cells was fully methylated irrespective of age. The selectivity for CD8 T cells correlated with lower [[DNMT1]] recruitment to the [[KIR2DL3]] promoter which further diminished with age. In contrast, binding of the polycomb protein [[EZH2]] known to be involved in [[DNMT1]] recruitment was not different. Our data suggest that CD8 T cells endure increasing displacement of [[DNMT1]] from the KIR promoter with age, possibly because of an active histone signature. The ensuing partial demethylation lowers the threshold for transcriptional activation and renders CD8 T cells more susceptible to express KIR, thereby contributing to the immune defect in the elderly.
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* CpG Islands
* DNA (Cytosine-5-)-Methyltransferase 1
* DNA (Cytosine-5-)-Methyltransferases
* DNA Methylation
* DNA-Binding Proteins
* Enhancer of Zeste Homolog 2 Protein
* Epigenesis, Genetic
* Female
* Humans
* Male
* Polycomb Repressive Complex 2
* Promoter Regions, Genetic
* Receptors, KIR2DL3
* Transcription Factors

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765678
}}