Редактирование: HSD11B1

Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-beta-hydroxysteroid dehydrogenase 1) (11-DH) (11-beta-HSD1) (Short chain dehydrogenase/reductase family 26C member 1) [HSD11] [HSD11L] [SDR26C1]

==Publications==

{{medline-entry
|title=Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 ([[HSD11B1]]) and lifetime cognitive change.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16236446
|abstract=A rare polymorphism in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 ([[HSD11B1]]: rs846911-C/A) has been associated with an increased risk of Alzheimer's disease. We tested the hypothesis that this and 2 other [[HSD11B1]] polymorphisms (rs12086634-G/T and rs846910-A/G) were associated with lifetime cognitive change in humans. Subjects were 194 participants of the Scottish Mental Survey of 1932 who took the same well-validated mental test at age 11 and age 79. The subjects represented the highest and lowest quintiles with respect to cognitive decline between ages 11 and 79. Despite having non-significantly different IQs at age 11, by age 79 the groups had mean (S.D.) IQs of 80.3 (14.1) and 109.6 (9.1), respectively (p<.001). The polymorphism rs846911-C/A was absent from both groups. There were no significant differences in the frequency of polymorphisms of rs12086634-G/T (p=.91) and rs846910-A/G (p=.90) between the groups. We conclude that these variants in [[HSD11B1]] are not significant contributors to the range of cognitive ageing examined here.
|mesh-terms=* 11-beta-Hydroxysteroid Dehydrogenase Type 1
* Aged
* Aging
* Cognition
* Cohort Studies
* Demography
* Female
* Humans
* Male
* Polymorphism, Genetic
* Time Factors

|full-text-url=https://sci-hub.do/10.1016/j.neulet.2005.09.047
}}