Редактирование: HNRNPA0

Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) [HNRPA0]

==Publications==

{{medline-entry
|title=The transcript expression levels of [[HNRNPM]], [[HNRNPA0]] and [[AKAP17A]] splicing factors may be predictively associated with ageing phenotypes in human peripheral blood.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31292793
|abstract=Dysregulation of splicing factor expression is emerging as a driver of human ageing; levels of transcripts encoding splicing regulators have previously been implicated in ageing and cellular senescence both in vitro and in vivo. We measured the expression levels of an a priori panel of 20 age- or senescence-associated splicing factors by qRT-PCR in peripheral blood samples from the InCHIANTI Study of Aging, and assessed longitudinal relationships with human ageing phenotypes (cognitive decline and physical ability) using multivariate linear regression. [[AKAP17A]], [[HNRNPA0]] and [[HNRNPM]] transcript levels were all predictively associated with severe decline in MMSE score (p = 0.007, 0.001 and 0.008 respectively). Further analyses also found expression of these genes was associated with a performance decline in two other cognitive measures; the Trail Making Test and the Purdue Pegboard Test. [[AKAP17A]] was nominally associated with a decline in mean hand-grip strength (p = 0.023), and further analyses found nominal associations with two other physical ability measures; the Epidemiologic Studies of the Elderly-Short Physical Performance Battery and calculated speed (m/s) during a timed 400 m fast walking test. These data add weight to the hypothesis that splicing dyregulation may contribute to the development of some ageing phenotypes in the human population.
|mesh-terms=* Aged
* Aging
* Antigens
* Cellular Senescence
* Cognitive Dysfunction
* Correlation of Data
* Female
* Hand Strength
* Heterogeneous-Nuclear Ribonucleoprotein Group M
* Heterogeneous-Nuclear Ribonucleoproteins
* Humans
* Male
* Membrane Glycoproteins
* Mental Status and Dementia Tests
* Physical Functional Performance
* Predictive Value of Tests
* RNA Splicing Factors
* Walking Speed
|keywords=* Biomarkers
* Cognitive decline
* Splicing factors
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733819
}}