Редактирование: HDGF

Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) [HMG1L2]

==Publications==

{{medline-entry
|title=Identification, cloning, and developmental expression of hepatoma-derived growth factor in the developing rat heart.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11747079
|abstract=Hepatoma derived growth factor ([[HDGF]]) was identified as a developmentally regulated cardiac gene by mRNA differential display using 12-day rat fetal conotruncus vs. newborn aorta. The full-length rat [[HDGF]] cDNA was cloned from a rat fetal heart cDNA library and found to be 94 and 88% homologous to the mouse and human sequence, respectively. The rat sequence, like the human and mouse, contains a highly conserved amino portion and putative bipartite nuclear localization sequence. By Northern analysis, [[HDGF]] is highly expressed in the fetal conotruncus, heart, kidney, brain, and gut. By immunocytochemistry, [[HDGF]] was first detected only in atrial myocytes, hind gut epithelia, and notochord of the E10 rat with a nuclear expression pattern. By E12, expression had broadened to include the ventricular myocytes, endocardial cells, and cells of the ventricular outflow tract. [[HDGF]] is unique in that it is the first described nuclear targeted growth factor in the developing heart. The early expression of [[HDGF]] in embryonic heart and fetal gut suggests that [[HDGF]] may play a role in cardiovascular growth and differentiation.
|mesh-terms=* Aging
* Amino Acid Sequence
* Animals
* Base Sequence
* Cardiovascular System
* Cloning, Molecular
* Embryo, Mammalian
* Embryonic and Fetal Development
* Gene Expression Profiling
* Gene Expression Regulation, Developmental
* Growth Substances
* Heart
* Intercellular Signaling Peptides and Proteins
* Molecular Sequence Data
* Myocardium
* Rats
* Rats, Sprague-Dawley
* Sequence Homology, Amino Acid
* Tissue Distribution

|full-text-url=https://sci-hub.do/10.1002/dvdy.1204
}}