Редактирование: GJA3

Gap junction alpha-3 protein (Connexin-46) (Cx46)

==Publications==

{{medline-entry
|title=Down-regulation of [[GJA3]] is associated with lens epithelial cell apoptosis and age-related cataract.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28088522
|abstract=Lens epithelial cell apoptosis is regarded as the common molecular basis of the initiation and subsequent progression of cataract. Recent studies have shown that Oxidative radicals derived from H2O2 causes lens epithelial cell apoptosis, While much work still needs to be done to elucidate this important mechanism of lens epithelial cell apoptosis induced by H2O2. The present study investigated the effect of human lens epithelial cell (SRA01/04) apoptosis induced by H2O2 and the possible molecular mechanism involved. Our data in this report has validated that H2O2 is an effective inducer of lens epithelial cells apoptosis, with the concentrations of H2O2 (100 μM). Moreover, we revealed that the down regulation of the [[GJA3]] gene was associated with H2O2-induced lens epithelial cells apoptosis. Over-expression of [[GJA3]] gene restrained the lens epithelial cells apoptosis induced by H2O2. Furthermore, [[GJA3]] V44 M mutation partly inhibited the capacity of [[GJA3]] to suppress apoptosis induced by H2O2 in SRA01/04 cells, eliciting the critical role of [[GJA3]] in H2O2-induced lens epithelial cells apoptosis. The in vivo results indicated that down-regulation of [[GJA3]] in lens epithelial cells was associated with age-related cataract genesis. Data from this study established the association of [[GJA3]] down regulation with lens epithelial cells apoptosis and age-related cataract genesis.
|mesh-terms=* Aging
* Animals
* Apoptosis
* Cataract
* Connexins
* Down-Regulation
* Epithelial Cells
* Humans
* Hydrogen Peroxide
* Lens, Crystalline
* Male
* Mice
* Mice, Inbred BALB C
|keywords=* Age-related cataract genesis
* GJA3
* H2O2
* Lens epithelial cells apoptosis
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2017.01.050
}}