Редактирование: FAIM

Fas apoptotic inhibitory molecule 1 [FAIM1]

==Publications==

{{medline-entry
|title=B cells from aged mice exhibit reduced apoptosis upon B-cell antigen receptor stimulation and differential ability to up-regulate survival signals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16367931
|abstract=During ageing, autoimmune disorders and the higher susceptibility to infectious have been associated with alterations in the humoral immune response. We report that splenic B lymphocytes from aged mice exhibit lower level of apoptosis induced by B-cell antigen receptor ([[BCR]]) ligation in vitro. Respect to B cells from young mice the anti-mu stimulated aged B cells show similar Bcl-2 and Bcl-xL expression but differential kinetic of A1 degradation and a higher level of cFLIP and [[FAIM]]. Even though B cells from aged mice show minor Fas expression they exhibit the same susceptibility to anti-Fas induced apoptosis. Aged B cells also present upon [[BCR]] stimulation, a higher proliferative response and similar level of activation markers expression than B cells from young mice. These data agree with the observation that aged mice exhibit an increment of T2 and mature B cell subset which rapidly enters cell cycle upon [[BCR]] engagement. The diminished apoptosis after activation in aged mice could compromise homeostatic mechanism allowing the persistence of self and non-self antigen specific B cells.
|mesh-terms=* Aging
* Animals
* Antigens
* Apoptosis
* Apoptosis Regulatory Proteins
* B-Lymphocyte Subsets
* Biomarkers
* Blotting, Western
* CASP8 and FADD-Like Apoptosis Regulating Protein
* Cell Survival
* Cells, Cultured
* Electrophoresis, Polyacrylamide Gel
* Female
* Flow Cytometry
* Inhibitor of Apoptosis Proteins
* Intracellular Signaling Peptides and Proteins
* Mice
* Mice, Inbred BALB C
* Receptors, Antigen, B-Cell
* Reverse Transcriptase Polymerase Chain Reaction
* Signal Transduction
* Up-Regulation
* fas Receptor

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809574
}}