Редактирование: ERBB4

Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Contains: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] [HER4]

==Publications==

{{medline-entry
|title=Overexpression of [[ERBB4]] rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30566395
|abstract=The age-related functional exhaustion limits potential efficacy of mesenchymal stem cells ([[MSC]]) in treating cardiovascular disease. Therefore, rejuvenation of aged [[MSC]] in the elderly population is of great interest. We have previously reported that Erb-B2 receptor tyrosine kinase 4 ( [[ERBB4]]) plays a critical role in regulating [[MSC]] survival under hypoxia. The aim of this study was to investigate whether [[ERBB4]] rejuvenates aged [[MSC]] and how [[ERBB4]] enhances therapeutic efficacy of aged [[MSC]] in treating myocardial infarction (MI). Compared with vector aged [[MSC]] (aged-[[MSC]]), [[ERBB4]]-engineered aged [[MSC]] (ER4-aged-[[MSC]]) conferred resistance to oxidative stress-induced cell death and ameliorated the senescent phenotype in vitro. Four weeks after MI, the ER4-aged-[[MSC]] group exhibited enhanced blood vessel density, reduced cardiac remodeling and apoptosis with improved heart function compared with the aged-[[MSC]] group. Overexpression of [[ERBB4]] caused an increase in phosphorylated v-akt murine thymoma viral oncogene homolog 1 (AKT), and phosphorylated ERK expression under hypoxia. ER4-aged-[[MSC]] secreted higher levels of angiopoietin, epithelial neutrophil activating peptide 78, VEGF, and fibroblast growth factor 2, and enhanced tube formation in HUVEC. The impact of [[ERBB4]] on protein expression, proangiogenesis, cell behavior, and cytokine secretion was abolished by inhibiting PI3K/AKT and MAPK/ERK signaling pathway.-Liang, X., Ding, Y., Lin, F., Zhang, Y., Zhou, X., Meng, Q., Lu, X., Jiang, G., Zhu, H., Chen, Y., Lian, Q., Fan, H., Liu, Z. Overexpression of [[ERBB4]] rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways.
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Animals
* Apoptosis
* Cells, Cultured
* Cellular Senescence
* Female
* Human Umbilical Vein Endothelial Cells
* Humans
* MAP Kinase Signaling System
* Male
* Mesenchymal Stem Cell Transplantation
* Mesenchymal Stem Cells
* Mice
* Mice, Inbred C57BL
* Mice, Inbred NOD
* Mice, SCID
* Myocardial Infarction
* Neovascularization, Physiologic
* Oxidative Stress
* Phosphatidylinositol 3-Kinases
* Proto-Oncogene Proteins c-akt
* Random Allocation
* Receptor, ErbB-4
* Recombinant Proteins
* Telomere Homeostasis
* Ventricular Remodeling
* Young Adult
|keywords=* MSC
* aging
* myocardial infarction
|full-text-url=https://sci-hub.do/10.1096/fj.201801690R
}}