Редактирование: EPHA3

Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) [ETK] [ETK1] [HEK] [TYRO4]

==Publications==

{{medline-entry
|title=A high-content cellular senescence screen identifies candidate tumor suppressors, including [[EPHA3]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23324396
|abstract=Activation of a cellular senescence program is a common response to prolonged oncogene activation or tumor suppressor loss, providing a physiological mechanism for tumor suppression in premalignant cells. The link between senescence and tumor suppression supports the hypothesis that a loss-of-function screen measuring bona fide senescence marker activation should identify candidate tumor suppressors. Using a high-content siRNA screening assay for cell morphology and proliferation measures, we identify 12 senescence-regulating kinases and determine their senescence marker signatures, including elevation of senescence-associated β-galactosidase, DNA damage and p53 or p16 (INK4a)  expression. Consistent with our hypothesis, SNP array CGH data supports loss of gene copy number of five senescence-suppressing genes across multiple tumor samples. One such candidate is the [[EPHA3]] receptor tyrosine kinase, a gene commonly mutated in human cancer. We demonstrate that selected intracellular [[EPHA3]] tumor-associated point mutations decrease receptor expression level and/or receptor tyrosine kinase (RTK) activity. Our study therefore describes a new strategy to mine for novel candidate tumor suppressors and provides compelling evidence that [[EPHA3]] mutations may promote tumorigenesis only when key senescence-inducing pathways have been inactivated.
|mesh-terms=* Cell Line, Tumor
* Cell Transformation, Neoplastic
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p16
* Gene Expression Profiling
* Gene Expression Regulation, Neoplastic
* High-Throughput Screening Assays
* Humans
* Models, Molecular
* Mutation
* Oligonucleotide Array Sequence Analysis
* Polymorphism, Single Nucleotide
* RNA, Small Interfering
* Receptor Protein-Tyrosine Kinases
* Receptor, EphA3
* Signal Transduction
* Tumor Suppressor Protein p53
* beta-Galactosidase
|keywords=* DDR
* EPHA3/RTK
* p16INK4a
* p53
* senescence
* tumor suppressor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594263
}}
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