Редактирование: DEFB4B

4A precursor (Beta-defensin 2) (BD-2) (hBD-2) (Defensin, beta 2) (Skin-antimicrobial peptide 1) (SAP1)

==Publications==

{{medline-entry
|title=Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31864349
|abstract=Despite being one of the major causes of infertility in mares, the mechanisms responsible for equine endometrosis are still unclear and controversial. In the last few years, many investigations focused on local immune response modulation. Since it is generally accepted that endometrial fibrosis increases with age, we hypothesize that older mares could show altered local immune modulation, initiating a pro-inflammatory and tissue remodeling cascade of events that could lead to endometrosis. The aim of this study, indeed, is to evaluate and describe the local gene expression of genes involved in acute inflammatory response and fibrosis (COL1A1, [[COL3A1]], TNFA, [[MMP9]], [[IL6]], [[TGFB1]] and TGFBR1), together with others associated to immune modulation ([[DEFB4B]], [[IDO1]] and [[FOXP3]]), in uterine specimens from mares of different age. Twenty-five Standardbred mares were involved in the study with age ranging from 7 to 19 years (mean 10.40 ± 4.42). They were divided by age into two groups: G1 (n = 15, less than 10 years old) and G2 (N = 10, greater than 11 years old). Specimens from the uterus' right horn-body junction were collected and processed for histology evaluation and RT-qPCR assay.Gene expression of [[DEFB4B]], [[MMP9]] and TNFA was higher in younger mares, suggesting a balance in immune modulation and tissue remodeling. Interleukin-6 and [[COL3A1]] gene expressions were greater in older animals, probably indicating inflammatory pathways activation and fibrosis increase. Although no differences in fibrosis and inflammation distribution could be found with histological examination among G1 and G2, our results suggest a possible involvement of DEF4BB in regulating the local immune response in younger mare's uterus (G1); age may contribute to the dis-regulation of [[DEFB4B]] transcription and, indirectly, influence the extracellular matrix homeostasis. Transcription of [[IDO1]] and [[FOXP3]] genes, instead, does not seem to be age related, or to be involved in local immune-response and tissue remodeling functions. Further investigations are needed in order to clarify the interactions between the expression of [[DEFB4B]], [[IL6]], TNFA, [[COL3A1]] and [[MMP9]] and other local signals of immune-modulation and tissue remodeling, in mares in a prospective study design.
|mesh-terms=* Aging
* Animals
* Breeding
* Defensins
* Endometrium
* Female
* Fibrosis
* Gene Expression
* Horses
* Inflammation
* Reverse Transcriptase Polymerase Chain Reaction
|keywords=* Defensin-β
* Endometrium
* Gene expression
* Immune-modulation
* Mare
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925900
}}