Редактирование: DEFB1

Beta-defensin 1 precursor (BD-1) (hBD-1) (Defensin, beta 1) [BD1] [HBD1]

==Publications==

{{medline-entry
|title=Association of Polymorphisms in Innate Immunity Genes [[TLR9]] and [[DEFB1]] with Human Longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26028230
|abstract=The distribution of polymorphic variants of innate immunity genes [[TLR9]] ( 2848G>A) and [[DEFB1]](-20G>A; -44C>G; -52G>A) was evaluated in long-living individuals. No significant differences were found in the distribution of genotypes and alleles of the [[TLR9]] gene. The following features were revealed: increase in the frequency of AA and GG genotypes and decrease in the frequency of the AG genotype of the [[DEFB1]](-20G>A) gene; increase in the frequency of the CC genotype and C allele and decrease in the frequency of CG and GG genotypes and G allele of the [[DEFB1]](44C>G) gene; and increase in the frequency of AA and AG genotypes and A allele and decrease in the frequency of the GG genotypes and G allele of the [[DEFB1]](-52G>A) gene. Genotypes and alleles of the [[DEFB1]] gene found in long-living individuals can be considered as the factors that increase the probability of longevity and favorable course of age-related diseases. 
|mesh-terms=* Adult
* Aged, 80 and over
* Aging
* Alleles
* DNA
* Gene Frequency
* Humans
* Immunity, Innate
* Longevity
* Middle Aged
* Polymorphism, Single Nucleotide
* Signal Transduction
* Toll-Like Receptor 9
* Young Adult
* beta-Defensins

|full-text-url=https://sci-hub.do/10.1007/s10517-015-2894-9
}}
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