Редактирование: CPQ

Carboxypeptidase Q precursor (EC 3.4.17.-) (Lysosomal dipeptidase) (Plasma glutamate carboxypeptidase) [LCH1] [PGCP]

==Publications==

{{medline-entry
|title=A Spanish Adaptation of the Computer and Mobile Device Proficiency Questionnaires ([[CPQ]] and MDPQ) for Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31214066
|abstract=Technology can help support the goal of many older adults to live independently, though cognitive, attitudinal, and other barriers often result in a "digital divide" in which older adults use and adopt new technology at a lower rate compared to younger adults. Due to the many potential benefits of technology it is not surprising that interest in tools that assess technology proficiency among older adults has increased. These tools can help support older adult technology research and training. However, to understand these issues more broadly, especially cross-cultural determinants of technology proficiency, translated, validated, and standardized measures of proficiency are necessary. For example, according to the last Eurobarometer (European Commission, 2015), Spain has experienced the largest increase in technology adoption among European Union nations in the past few years, indicating potential cultural mediation of technology adoption and use. To benefit the investigation of cross-cultural differences and their causes, we adapted the Mobile Device Proficiency Questionnaire (MDPQ) and Computer Proficiency Questionnaire ([[CPQ]]) for older adults in Spain, including the full and brief forms of each measure. Consistent with English versions of the questionnaires, the scales and their subscales were found to be reliable and valid measures of mobile device and computer proficiency in Spanish older adults. However, in contrast to earlier studies, the factor structure for both questionnaires simplified into two factors for the population under study. We conclude that the Spanish versions of the MDPQ and [[CPQ]] can be employed as useful tools for measuring mobile device and computer proficiency in the Spanish older adult population for research and training purposes.

|keywords=* Spanish translation
* age related differences
* aging
* computer proficiency
* digital divide
* digitalization
* mobile device proficiency
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554441
}}
{{medline-entry
|title=Protective Effect of Semisynthetic and Natural Flavonoid on Aged Rat Microglia-enriched Cultures.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31230229
|abstract=The ROS-mediated lysosomal dysfunction and coinciding deterioration of mitochondrial function are thought to be the prominent mechanisms responsible for aging. Microglia, the resident macrophages in the central nervous system, were postulated to belong to the major targets vulnerable to these detrimental processes, acting as principal drivers in brain aging. The present study investigated the potential protective effect of the semisynthetic flavonoid 3'-O-(3-chloropivaloyl) quercetin ([[CPQ]]) and quercetin (Q) on microglia-enriched mixed brain cultures (MBCs) established from aged Wistar rats. Both flavonoids tested suppressed the development of lipofuscin-related autofluorescence in aged cells. Further ensuing protective effects included reduction of protein oxidation markers in aged cells. Moreover, unlike Q, [[CPQ]] significantly suppressed sensitivity of aged cells to stimulation of superoxide burst. Other activation markers, cellular hypertrophy and isolectin B4 binding, were also downregulated by treatment with both [[CPQ]] and Q. In conclusion, results of our study suggest that both flavonoids tested may protect microglia with a quite comparable efficacy against aging-related accumulated alterations. The protective mechanism can include interference with the ROS-mediated vicious cycles involving lysosomal dysfunction. Nevertheless, the lipophilized quercetin, [[CPQ]], a compound with proposed enhanced biological availability compared to parent molecule, can represent an agent potentially useful for new effective pharmaceutical intervention against brain aging, overcoming the limitations of clinical applicability of quercetin.
|mesh-terms=* Aging
* Animals
* Cells, Cultured
* Flavonoids
* Lipofuscin
* Male
* Microglia
* Mitochondria
* Oxidative Stress
* Quercetin
* Rats, Wistar
* Reactive Oxygen Species
|keywords=* Aging
* Flavonoids
* Lipofuscin
* Microglia
* Mitochondria
* ROS
|full-text-url=https://sci-hub.do/10.1007/s12640-019-00071-5
}}