Редактирование: CHIA

Acidic mammalian chitinase precursor (EC 3.2.1.14) (AMCase) (Lung-specific protein TSA1902)

==Publications==

{{medline-entry
|title=Lipoprotein Profile in Aged Rats Fed Chia Oil- or Hydroxytyrosol-Enriched Pork in High Cholesterol/High Saturated Fat Diets.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30486328
|abstract=Restructuring pork (RP) by adding new functional ingredients, like Chia oil (one of the richest natural source of α-linolenic acid) or hydroxytyrosol (HxT) (potent antioxidant), both with hypolipidemic activities, is one of the strategies that may help to reduce the potential negative effects of high meat products consumption. The aim of this study was to evaluate the Chia oil- or HxT-enriched-RP effect on the lipoprotein profile of aged rats fed high-fat, high-energy, and cholesterol-enriched diets. RP samples were prepared by mixing lean pork and lard with or without Chia oil (152.2 g/kg fresh matter) or HxT (3.6 g/kg fresh matter). Diets were prepared by mixing a semisynthetic diet with freeze-dried RP. Groups of 1-year male Wistar rats were fed the following experimental diets for 8 weeks: C, control-RP diet; HC, cholesterol-enriched-RP diet; and Chia oil-RP ([[CHIA]]) and HxT, Chia oil- or hydroxytyrosol-RP, cholesterol-enriched diet. Plasma lipid, lipoprotein profile, SREBP-1c protein, and low-density lipoproteins (LDL) receptor gene ([i]Ldlr[/i]) expressions were evaluated. Compared to C diet, the HC diet increased plasma cholesterol, triglycerides, free fatty acids, total lipids, and SREBP-1c expression, but reduced [i]Ldlr[/i] expression and significantly modified the lipoprotein profile, giving rise to the presence of high levels of atherogenic cholesterol-enriched very low-density lipoproteins (VLDL) particles. Compared to the HC diet, the HxT diet did not produce significant changes in feed intake but it reduced the body weight. Chia oil and HxT partially arrested the negative effects of the high-fat, high-energy, and cholesterol-enriched meat-based diets on lipemia and lipoproteinemia, mostly by reducing the amount of cholesterol content in VLDL (60% and 74% less in [[CHIA]] and HxT vs. HC, respectively) and the VLDL total mass (59% and 63% less in [[CHIA]] and HxT vs. HC, respectively). Free fatty acids (FFA) significantly correlated with adipose tissue weight and VLDL total mass (both [i]p[/i] < 0.05), and plasma triglycerides, phospholipids, total lipids, and SREBP-1c (all [i]p[/i] < 0.001), suggesting the important role of FFA in lipoprotein metabolism. Results support the recommendation to include these ingredients in pork products addressed to reduce the presence of increased atherogenic particles in aged people at CVD risk consuming large amounts of pork.
|mesh-terms=* Adipose Tissue
* Animals
* Antioxidants
* Cholesterol, Dietary
* Diet, High-Fat
* Fatty Acids
* Lipoproteins, LDL
* Lipoproteins, VLDL
* Male
* Phenylethyl Alcohol
* Phospholipids
* Plant Oils
* Rats, Wistar
* Receptors, LDL
* Red Meat
* Salvia
* Seeds
* Sterol Regulatory Element Binding Protein 1
* Swine
* Triglycerides
* alpha-Linolenic Acid
|keywords=* Chia oil
* aging
* hydroxytyrosol
* lipoprotein
* restructured pork
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316572
}}
{{medline-entry
|title=Chia Oil-Enriched Restructured Pork Effects on Oxidative and Inflammatory Status of Aged Rats Fed High Cholesterol/High Fat Diets.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28294699
|abstract=Chia oil has the highest recognized α-linolenic acid (ALA) content. ALA is associated with beneficial changes in plasma lipids and the prevention of cardiovascular diseases. Present article aims to analyze the effect of Chia oil-enriched restructured pork (RP) on aged rats in a nonalcoholic steatohepatitis (NASH) model. Groups of six male Wistar rats (1-year old) were fed the experimental diets: control RP diet (C) noncholesterol high saturated; cholesterol-enriched high-saturated fat/high-cholesterol control RP diet (HC) with added cholesterol and cholic acid; and Chia oil- or Hydroxytyrosol RP cholesterol-enriched high-saturated fat/high cholesterol ([[CHIA]] and HxT). Total cholesterol, hepatosomatic index, Nrf2, antioxidant, and inflammation markers were determined. [[CHIA]] reduced the hypercholesterolemic effect by lowering levels similar to C; also, ameliorated redox index. [[CHIA]], despite high polyunsaturated fatty acids (PUFA) content, reduced thiobarbituric acid reactive substances (TBARS) and induced the lowest SOD protein synthesis but not a reduction on its activity. Chia oil activated the Nrf2 to arrest the pro-oxidative response to cholesterol and aging. Endothelial nitric oxide synthase (eNOS) system was lower in HxT than in [[CHIA]], suggesting its antiatherogenic activity and related protective effect against high PUFA. Increase in tumor necrosis factor alpha (TNFα) was partially blocked by [[CHIA]]. Chia oil has the ability to prevent oxidative damage and modify the inflammatory response, suggesting adequate regulation of the antioxidant system. Results stress the importance of incorporating ALA into the diet.
|mesh-terms=* Aging
* Animals
* Cholesterol, Dietary
* Diet, High-Fat
* GA-Binding Protein Transcription Factor
* Humans
* Hypercholesterolemia
* Male
* Meat
* Non-alcoholic Fatty Liver Disease
* Oxidative Stress
* Plant Oils
* Rats
* Rats, Wistar
* Salvia
* Swine
* Tumor Necrosis Factor-alpha
|keywords=* NASH
* ageing
* antioxidant
* cholesterol
* inflammation
* restructured pork
|full-text-url=https://sci-hub.do/10.1089/jmf.2016.0161
}}