Редактирование: CGN

Cingulin [KIAA1319]

==Publications==

{{medline-entry
|title=Effect of N-methyl-D-aspartate receptor blockade on caspase activation and neuronal death in the developing rat cerebellum.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16781062
|abstract=In vitro studies have demonstrated that N-methyl-D-aspartate (NMDA) receptor activation rescue cerebellar granule neurons ([[CGN]]) from apoptotic death. It has been suggested that this effect mimics the transient glutamate receptors activation by mossy fibers during cerebellar development. We reported previously that [[CGN]] from postnatal days 2-4 (P2-P4) rats increased cell survival in response to NMDA treatment. In this study, we evaluated the effect of dizocilpine (MK-801) administrated for three consecutive days on the apoptotic death of [[CGN]] during development. MK-801 treatment decreased the large number of [[CGN]] condensed nuclei found at P8, but this drug increased the proportion of condensed nuclei at P16. We also found a high activity of caspases during the first postnatal week that decreased during development. MK-801 treatment did not modify the activity of caspase-8 at any age, but decreased caspase-9 activity at P8 and increased the activity of caspase-1 (76%) at P8, caspase-3 (160%) at P16 and caspase-9 (50%) at P12. These results suggest that NMDA receptor stimulation regulates the activity of caspases in a differential way and plays an important role in the in vivo [[CGN]] death during postnatal development.
|mesh-terms=* Aging
* Animals
* Caspases
* Cerebellum
* Dizocilpine Maleate
* Enzyme Activation
* Excitatory Amino Acid Antagonists
* Models, Animal
* Rats
* Rats, Wistar
* Receptors, N-Methyl-D-Aspartate

|full-text-url=https://sci-hub.do/10.1016/j.neulet.2006.05.039
}}