Редактирование: CEP95

protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) [CCDC45] [CEP45]

==Publications==

{{medline-entry
|title=Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24478790
|abstract=Leukocyte telomere length is believed to measure cellular aging in humans, and short leukocyte telomere length is associated with increased risks of late onset diseases, including cardiovascular disease, dementia, etc. Many studies have shown that leukocyte telomere length is a heritable trait, and several candidate genes have been identified, including [[TERT]], TERC, OBFC1, and [[CTC1]]. Unlike most studies that have focused on genetic causes of chronic diseases such as heart disease and diabetes in relation to leukocyte telomere length, the present study examined the genome to identify variants that may contribute to variation in leukocyte telomere length among families with exceptional longevity. From the genome wide association analysis in 4,289 LLFS participants, we identified a novel intergenic SNP rs7680468 located near [[PAPSS1]] and [[DKK2]] on 4q25 (p = 4.7E-8). From our linkage analysis, we identified two additional novel loci with HLOD scores exceeding three, including 4.77 for 17q23.2, and 4.36 for 10q11.21. These two loci harbor a number of novel candidate genes with SNPs, and our gene-wise association analysis identified multiple genes, including [[DCAF7]], [[POLG2]], [[CEP95]], and [[SMURF2]] at 17q23.2; and [[RASGEF1A]], [[HNRNPF]], ANF487, [[CSTF2T]], and [[PRKG1]] at 10q11.21. Among these genes, multiple SNPs were associated with leukocyte telomere length, but the strongest association was observed with one contiguous haplotype in [[CEP95]] and [[SMURF2]]. We also show that three previously reported genes-TERC, [[MYNN]], and OBFC1-were significantly associated with leukocyte telomere length at p empirical < 0.05. 

|keywords=* aging
* familial longevity
* family-based study
* genome wide association and linkage
* novel genes
* telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894567
}}