Редактирование: CDC73

Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) [C1orf28] [HRPT2]

==Publications==

{{medline-entry
|title=Down-regulation of cancer-associated gene [[CDC73]] contributes to cellular senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29621547
|abstract=Dysregulated gene expression is another important contributor in explaining cancer-related phenotypes in addition to mutations. Cellular senescence is a mechanism for the prevention of cancer and thus it is important to understand the regulation of gene expression in senescence due to its potential in anti-cancer therapy. Here, we found that [[CDC73]], which encodes the cell division cycle 73 and acts as a tumor suppressor, was unexpectedly up-regulated in several cancer types but down-regulated in a variety of senescent cells. Importantly, depletion of [[CDC73]] could induce senescence-associated phenotypes in both normal and cancer cells, with an increase in p21 expression. In terms of molecular mechanism, alternative polyadenylation (APA)-mediated 3' untranslated region (3' UTR) lengthening explained, at least in part, the decreased [[CDC73]] expression in senescent cells because longer 3' UTR had a higher rate of RNA degradation compared to the shorter one. Our work discovered that post-transcriptional down-regulation of [[CDC73]] contributed to cellular senescence.
|mesh-terms=* 3' Untranslated Regions
* Base Sequence
* Cell Line
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* Down-Regulation
* Gene Expression Regulation, Neoplastic
* Gene Knockdown Techniques
* Humans
* Neoplasms
* Tumor Suppressor Proteins
* Up-Regulation
|keywords=* 3′ UTR
* CDC73
* Cancer
* Cellular senescence
* Gene expression
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2018.03.228
}}