Редактирование: CCR9

C-C chemokine receptor type 9 (C-C CKR-9) (CC-CKR-9) (CCR-9) (G-protein coupled receptor 28) (GPR-9-6) (CDw199 antigen) [GPR28]

==Publications==

{{medline-entry
|title=Attenuation of migration properties of CD4  T cells from aged mice correlates with decrease in chemokine receptor expression, response to retinoic acid, and RALDH expression compared to young mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25036122
|abstract=Aging results in attenuation of abilities to mount appropriate immune responses. The influence of aging on CD4( ) T cell migration ability toward chemokines was investigated with young and aged mice. We found functional decline in migration ability toward CCL19 and also decreased CCR7 expression level in antigen-stimulated CD4( ) T cells from aged mice compared with those from young mice. Upon addition of retinoic acid (RA), CD4( ) T cells from aged mice showed decreased [[CCR9]] expression level compared to young mice and the migration ability of CD4( ) T cells from aged mice toward CCL25 was attenuated compared to young mice. We also observed that the expression of RALDH2 mRNA was decreased in mesenteric lymph node dendritic cells from aged mice compared to those from young mice. These results demonstrate that attenuated migration abilities of CD4( ) T cells were observed in aged mice, which correlated with decreased chemokine receptor expression. Furthermore, the reduced production and response to RA by aging may be one of the causes of such attenuated migration abilities in the intestinal immune system. 
|mesh-terms=* Aging
* Aldehyde Dehydrogenase 1 Family
* Aldehyde Oxidoreductases
* Animals
* CD4-Positive T-Lymphocytes
* Cell Movement
* Chemokine CCL19
* Chemokines, CC
* Female
* Gene Expression Regulation, Enzymologic
* Integrins
* Isoenzymes
* Mice
* RNA, Messenger
* Receptors, CCR
* Receptors, CCR7
* Receptors, Chemokine
* Retinal Dehydrogenase
* Spleen
* Tretinoin
|keywords=* T cell
* aging
* migration
|full-text-url=https://sci-hub.do/10.1080/09168451.2014.910099
}}
{{medline-entry
|title=A role for [[CCR9]] in T lymphocyte development and migration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11884450
|abstract=[[CCR9]] mediates chemotaxis in response to CCL25/thymus-expressed chemokine and is selectively expressed on T cells in the thymus and small intestine. To investigate the role of [[CCR9]] in T cell development, the [[CCR9]] gene was disrupted by homologous recombination. B cell development, thymic alphabeta-T cell development, and thymocyte selection appeared unimpaired in adult [[CCR9]]-deficient ([[CCR9]](-/-)) mice. However, competitive transplantation experiments revealed that bone marrow from [[CCR9]](-/-) mice was less efficient at repopulating the thymus of lethally irradiated Rag-1(-/-) mice than bone marrow from littermate [[CCR9]]( / ) mice. [[CCR9]](-/-) mice had increased numbers of peripheral gammadelta-T cells but reduced numbers of gammadeltaTCR( ) and CD8alphabeta( )alphabetaTCR( ) intraepithelial lymphocytes in the small intestine. Thus, [[CCR9]] plays an important, although not indispensable, role in regulating the development and/or migration of both alphabeta(-) and gammadelta(-) T lymphocytes.
|mesh-terms=* Aging
* Animals
* B-Lymphocyte Subsets
* Bone Marrow Cells
* Cell Differentiation
* Cells, Cultured
* Chemotaxis, Leukocyte
* Crosses, Genetic
* Hematopoiesis
* Intestinal Mucosa
* Lymph Nodes
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Organ Specificity
* Receptors, Antigen, T-Cell, alpha-beta
* Receptors, Antigen, T-Cell, gamma-delta
* Receptors, CCR
* Receptors, Chemokine
* Spleen
* T-Lymphocyte Subsets
* Thymus Gland

|full-text-url=https://sci-hub.do/10.4049/jimmunol.168.6.2811
}}
{{medline-entry
|title=Age-related changes in [[CCR9]]  circulating lymphocytes: are [[CCR9]]  naive T cells recent thymic emigrants?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11696193
|abstract=The chemokine receptor [[CCR9]] is reported to be predominantly expressed by thymocytes as well as by circulating gut-homing and resident T cells in the small intestinal mucosa. Its ligand thymus-expressed chemokine (TECK) is produced by thymic and small intestinal epithelium. Here we report that the proportion of circulating [[CCR9]]  naive T cells (mostly CD4 ) declines with age, from approximately 15% of all T cells at birth to around 1% in adults. The proportion of [[CCR9]]  T cells lacking the classical gut-homing receptor alpha4beta7, was much higher in children than in adults. Therefore, circulating CD3 [[CCR9]] CD45RA  cells have most likely left the thymus quite recently. This notion was supported by the small number of [[CCR9]]  naive T cells which was present shortly after thymectomy. Establishing a phenotypic marker for recent thymic emigrants might provide a powerful tool in the clinical assessment and follow-up after cancer chemotherapy, hematopoietic stem cell transplantation, and during antiretroviral treatment of human immunodeficiency virus (HIV)-infected patients.
|mesh-terms=* Adolescent
* Adult
* Aged
* Aging
* CD3 Complex
* CD4-Positive T-Lymphocytes
* Cell Movement
* Child
* Child, Preschool
* Flow Cytometry
* Humans
* Infant
* Infant, Newborn
* Leukocyte Common Antigens
* Middle Aged
* Receptors, CCR
* Receptors, Chemokine
* T-Lymphocyte Subsets
* Thymectomy
* Thymus Gland

|full-text-url=https://sci-hub.do/10.1046/j.1365-3083.2001.01008.x
}}
{{medline-entry
|title=Expression of [[CCR9]] beta-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8( ) T cells from secondary lymphoid organs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11159507
|abstract=Chemokines appear to have an important role in the seeding of lymphoid progenitors in the thymus, the regulation of the coordinated movements of the maturing T cells within this organ, and the egress of the resulting naive T cells to secondary lymphoid organs. [[CCR9]], the specific receptor for the beta-chemokine TECK/[[CCL25]], is selectively expressed in thymus, lymph node, and spleen. Using a specific anti-[[CCR9]] polyclonal antibody, K629, and a semiquantitative reverse transcriptase-polymerase chain reaction procedure, a detailed study of [[CCR9]] expression in the thymus and secondary lymphoid organs was performed. The results show that CD4( )CD8( ) double-positive thymocytes have the highest [[CCR9]] expression in thymus. Single-positive CD8( ) thymocytes continue to express this receptor after abandoning the thymus as mature naive T cells, as suggested by the existence of a CD8( )CD69(low)CD62L(high) [[CCR9]]( ) cell subset. Consistent with this, CD8( ) lymphocytes from lymph nodes, spleen, and Peyer patches express a functional [[CCR9]], as its expression correlates with migration in response to [[CCL25]]. Conversely, CD4( ) thymocytes lose [[CCR9]] before abandoning the thymus, and CD4( ) T cells from secondary lymphoid organs also lack [[CCR9]] expression. Analysis of [[CCR9]] expression in thymocytes from mice of different ages showed that [[CCR9]] levels are affected by age, as this receptor is more abundant, and its response to [[CCL25]] is more potent in newborn animals. Collectively, these results suggest that [[CCR9]] has a role in thymocyte development throughout murine life, with clear differences between the CD4( ) and CD8( ) lineages.
|mesh-terms=* Aging
* Animals
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Cell Differentiation
* Cell Lineage
* Chemokines, CC
* Chemotaxis
* DNA-Binding Proteins
* Gene Expression Profiling
* Lymph Nodes
* Lymphoid Tissue
* Mice
* Mice, Inbred BALB C
* Mice, Knockout
* Muromonab-CD3
* Peyer's Patches
* RNA, Messenger
* Rabbits
* Receptors, CCR
* Receptors, Chemokine
* Recombinant Fusion Proteins
* Reverse Transcriptase Polymerase Chain Reaction
* Spleen
* T-Lymphocyte Subsets
* Thymus Gland
* Transfection

|full-text-url=https://sci-hub.do/10.1182/blood.v97.4.850
}}