Редактирование: CABLES1

CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) [CABLES]

==Publications==

{{medline-entry
|title=[[CABLES1]] Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31327733
|abstract=Bone marrow (BM) niche cells help to keep adult hematopoietic stem cells (HSCs) in a quiescent state via secreted factors and induction of cell-cycle inhibitors. Here, we demonstrate that the adapter protein [[CABLES1]] is a key regulator of long-term hematopoietic homeostasis during stress and aging. Young mice lacking Cables1 displayed hyperproliferation of hematopoietic progenitor cells. This defect was cell intrinsic, since it was reproduced in BM transplantation assays using wild-type animals as recipients. Overexpression and short hairpin RNA-mediated depletion of [[CABLES1]] protein resulted in p21  up- and downregulation, respectively. Aged mice lacking Cables1 displayed abnormalities in peripheral blood cell counts accompanied by a significant reduction in HSC compartment, concomitant with an increased mobilization of progenitor cells. In addition, Cables1  mice displayed increased sensitivity to the chemotherapeutic agent 5-fluorouracil due to an abnormal microenvironment. Altogether, our findings uncover a key role for [[CABLES1]] in HSC homeostasis and stress hematopoiesis.
|mesh-terms=* Aging
* Animals
* Antigens, CD34
* Bone Marrow Cells
* Cell Cycle Checkpoints
* Cell Proliferation
* Cyclin-Dependent Kinase Inhibitor p21
* Cyclins
* Fluorouracil
* Hematopoiesis
* Hematopoietic Stem Cell Transplantation
* Hematopoietic Stem Cells
* Humans
* Lipopolysaccharides
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* RNA Interference
* RNA, Small Interfering
|keywords=* CABLES1
* cell cycle
* hematopoietic niches
* hematopoietic stem cell homeostasis
* mesenchymal stromal cells
* p21
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700604
}}