Редактирование: BRD7

Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) [BP75] [CELTIX1]

==Publications==

{{medline-entry
|title=[[XIAP]]-associating factor 1, a transcriptional target of [[BRD7]], contributes to endothelial cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26802028
|abstract=X-linked inhibitor of apoptosis ([[XIAP]])-associated factor 1 ([[XAF1]]) is well known as an antagonist of [[XIAP]]-mediated caspase inhibition. Although [[XAF1]] serves as a tumor-suppressor gene, the role of [[XAF1]] in cellular senescence remains unclear. We found that [[XAF1]] expression was increased by genotoxic agents, such as doxorubicin and ionizing radiation in pulmonary microvascular endothelial cells, consequently leading to premature senescence. Conversely, downregulation of [[XAF1]] in premature senescent cells partially overcame endothelial cell senescence. p53 knockdown, but not p16 knockdown, abolished senescence phenotypes caused by [[XAF1]] induction. [[XAF1]] expression was transcriptionally regulated by Bromodomain 7 ([[BRD7]]). [[XAF1]] induction with interferon-gamma (IFN-γ) treatment was abrogated by [[BRD7]] knockdown, which resulted in blocking interferon-induced senescence. In lung cancer cells, [[XAF1]] tumor suppressor activity was decreased by [[BRD7]] knockdown, and inhibition of tumor growth by IFN-γ did not appear in [[BRD7]]-depleted xenograft tumors. These data suggest that [[XAF1]] is involved in [[BRD7]]-associated senescence and plays an important role in the regulation of endothelial senescence through a p53-dependent pathway. Furthermore, regulation of the [[BRD7]]/[[XAF1]] system might contribute to tissue or organismal aging and protection against cellular transformation. 
|mesh-terms=* Cell Line, Tumor
* Cellular Senescence
* Chromosomal Proteins, Non-Histone
* Endothelial Cells
* Humans
* Neoplasm Proteins
* Transfection
* X-Linked Inhibitor of Apoptosis Protein
|keywords=* BRD7
* DNA damage
* Gerotarget
* XAF1
* cellular senescence
* ionizing radiation
* p53
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868675
}}